► Design of experiments can efficiently optimise a chromatographic response by finding best values of factors. ► DoE with a Plackett–Burman design can be used in method validation to show robustness ...of a method. ► Central composite designs (CCD) are the most used for optimisation of 2–5 factors. ► Box–Behnken and Doehlert designs can be more efficient than CCD. ► D-optimal designs are used when the factor space is restricted or numbers of possible experiments is limited.
The ability of a chromatographic method to successful separate, identify and quantitate species is determined by many factors, many of which are in the control of the experimenter. When attempting to discover the important factors and then optimise a response by tuning these factors, experimental design (design of experiments, DoE) gives a powerful suite of statistical methodology. Advantages include modelling by empirical functions, not requiring detailed knowledge of the underlying physico-chemical properties of the system, a defined number of experiments to be performed, and available software to accomplish the task. Two uses of DoE in chromatography are for showing lack of significant effects in robustness studies for method validation, and for identifying significant factors and then optimising a response with respect to them in method development. Plackett–Burman designs are widely used in validation studies, and fractional factorial designs and their extensions such as central composite designs are the most popular optimisers. Box–Behnken and Doehlert designs are becoming more used as efficient alternatives. If it is not possible to practically realise values of the factors required by experimental designs, or if there is a constraint on the total number of experiments that can be done, then D-optimal designs can be very powerful. Examples of the use of DoE in chromatography are reviewed. Recommendations are given on how to report DoE studies in the literature.
Taking as its point of departure Roland Barthes’ classic series of essays, Mythologies, Rebecca Houze presents an exploration of signs and symbols in the visual landscape of postmodernity. In nine ...chapters Houze considers a range of contemporary phenomena, from the history of sustainability to the meaning of sports and children’s building toys. Among the ubiquitous global trademarks she examines are BP, McDonald’s, and Nike. What do these icons say to us today? What political and ideological messages are hidden beneath their surfaces? Taking the idea of myth in its broadest sense, the individual case studies employ a variety of analytic methods derived from linguistics, psychoanalysis, anthropology, sociology, and art history. In their eclecticism of approach they demonstrate the interdisciplinarity of design history and design studies. Just as Barthes’ meditations on culture concentrated on his native France, New Mythologies is rooted in the author’s experience of living and teaching in the United States. Houze’s reflections encompass both contemporary American popular culture and the history of American industry, with reference to such foundational figures as Thomas Jefferson and Walt Disney. The collection provides a point of entry into today’s complex postmodern or post-postmodern world, and suggests some ways of thinking about its meanings, and the lessons we might learn from it.
Covering the 1960s and 1970s, this volume explores new ways of investigating, comparing and interpreting the different domains of design culture across the Nordic countries. Challenging the ...traditional narrative, this volume argues that the roots of the most prominent features of Nordic design’s contemporary significance are not to be found amongst the objects for the home collectively branded as ‘Scandinavian Design’ to great acclaim in the 1950s, but in the discourses, institutions and practices formed in the aftermath of that oft-told success story, during the turbulent period between 1960 and 1980. This is achieved by employing multidisciplinary approaches to connect the domains of industrial production, marketing, consumption, public institutions, design educations, trade journals as well as public debates and civic initiatives forming a design culture. This book makes a significant contribution to current, international agendas of historiographical critique focusing on transnational relations and the deconstruction of national design histories. This book will be of interest to scholars in design, design history and Scandinavian studies.
How do we design for users? How might users best participate in the design process? How can we evaluate the user's experience of designed products and services? These fundamental questions are ...addressed in Designers, Users, and Justice, through a series of dialogues between a design scholar and a designer. In a series of conversations, the scholar and the designer address the concepts and practice of user centred design, examining whether a 'just method' necessarily leads to a just design, consider different models for understanding user experience and socially productive design, including the capability approach and utilitarianism, and ponder how an ethical framework for evaluating design might be developed. Throughout, the scholar and the designer draw on their particular experiences in design practice and design education, and propose alternative conceptualisations of the key ideas of user centred design, highlighting and seeking to address the ethical shortcomings of mainstream user centred design practice.
'Digital Architecture Beyond Computers' explores the deep history of digital architecture, tracing design concepts as far back as the Renaissance and connecting them with the latest software used by ...designers today. It develops a critical account of how the tools and techniques of digital design have emerged, and allows designers to deepen their understanding of the digital tools they use every day. What aesthetic, spatial, and philosophical concepts converge within the digital tools architects employ? What is their history? And what kinds of techniques and designs have they given rise to?
The phenomenal growth of global pharmaceutical sales and the quest for innovation are driving an unprecedented search for human test subjects, particularly in middle- and low-income countries. Our ...hope for medical progress increasingly depends on the willingness of the world's poor to participate in clinical drug trials. While these experiments often provide those in need with vital and previously unattainable medical resources, the outsourcing and offshoring of trials also create new problems. In this groundbreaking book, anthropologist Adriana Petryna takes us deep into the clinical trials industry as it brings together players separated by vast economic and cultural differences. Moving between corporate and scientific offices in the United States and research and public health sites in Poland and Brazil,When Experiments Traveldocuments the complex ways that commercial medical science, with all its benefits and risks, is being integrated into local health systems and emerging drug markets.
Providing a unique perspective on globalized clinical trials,When Experiments Travelraises central questions: Are such trials exploitative or are they social goods? How are experiments controlled and how is drug safety ensured? And do these experiments help or harm public health in the countries where they are conducted? Empirically rich and theoretically innovative, the book shows that neither the language of coercion nor that of rational choice fully captures the range of situations and value systems at work in medical experiments today.When Experiments Travelchallenges conventional understandings of the ethics and politics of transnational science and changes the way we think about global medicine and the new infrastructures of our lives.
This proven and internationally recognized text teaches the methods of engineering design as a condition of successful product development. It breaks down the design process into phases and then into ...distinct steps, each with its own working methods.
