Our objective was to develop and qualify a bioanalytical method for the estimation of di-18:1-bis(monoacylglycero)phosphate (di-18:1 BMP) as a urinary biomarker for the assessment of drug-induced ...phospholipidosis and demonstrate its application in a preclinical study.
di-18:1 BMP was extracted by liquid-liquid extraction using n-butanol and analyzed by LC-MS/MS. The qualified method was selective, precise, robust and accurate across the linearity range (0.2-250 ng/ml). Qualified method was then used to assess chloroquine-induced phospholipidosis in rats dosed at 120 mg/kg for 5 days. A fivefold increase in di-18:1 BMP was observed on Day 5 compared with predose.
Di-18:1 BMP can be used as a noninvasive biomarker to assess/screen compounds that could cause drug-induced phospholipidosis in rats.
Richly illustrated with case studies and interviews, this book identifies key themes pervading academic life: the nature of research and research supervision; key social processes and problems; ...distinct and contrasting sub-cultures of departments and disciplines in universities; mentorship and sponsorship; and apprenticeship and rites of passage for postgraduate students. Anyone developing policy and practice in Higher Education, or wishing to understand their own position within the wider picture will benefit from reading this book.
A must read for all research students!
"The core material in Professor Cryer's previous editions is classic. I welcome this new edition setting it into current contexts."- PhD supervisor
"When I was ...doing my own PhD, Pat Cryer's book was my constant reference companion. Now I am recommending her latest edition to my own students."- PhD supervisor
Insightful, wide-ranging and accessible, this is an invaluable tool for postgraduate research students and for students at all levels working on research projects, irrespective of their field of study.This edition has been thoroughly revised to accommodate the changes in postgraduate education over recent years. Additional material and new emphases take into account:
the QAA Code of Practice for Postgraduate Research Programmesrecommendations of the Roberts Reviewthe needs of the growing number of 'overseas' research studentsemployment issues (including undergraduate teaching)the Internet as a resource for research.There are new chapters on:
developing the research proposalsucceeding as an 'overseas' research studentethics in researchpersonal development planning (PDP)
Economists seem to be everywhere in the media these days. But what exactly do today's economists do? What and how are they taught? Updating David Colander and Arjo Klamer's classic The Making of an ...Economist, this book shows what is happening in elite U.S. economics Ph.D. programs. By examining these programs, Colander gives a view of cutting-edge economics--and a glimpse at its likely future. And by comparing economics education today to the findings of the original book, the new book shows how much--and in what ways--the field has changed over the past two decades. The original book led to a reexamination of graduate education by the profession, and has been essential reading for prospective graduate students. Like its predecessor, The Making of an Economist, Redux is likely to provoke discussion within economics and beyond.
Offers guidance to enable library and information science professionals to support the specialist needs of research students effectively. This book covers such key areas as: research and the research ...process; the research student's experience; research skills training; introduction to research communities; and, professional development.
Blacks in the white elite Zweigenhaft, Richard L; Zweigenhaft, Richard L; Domhoff, G. William
2003., 2003, 2003-08-01, 20030101
eBook
This extensively revised edition of Blacks in the White Establishment? adds fifteen years to the life stories of the African Americans whose opportunities were dramatically changed by a nationally ...prominent educational opportunity program that provided scholarships for disadvantaged people of color to attend the same elite boarding schools that educate the children of wealthy white Americans. Beyond tracing the individuals into middle age, and expanding coverage of their careers, with special attention to experiences in the corporate world, a new chapter on their children's education and early careers gives the new edition a poignant and unusual intergenerational perspective. Blacks in the White Elite shows why America is at a crucial juncture in relations between blacks and whites, when advances made since the Civil Rights Movement could either continue or retrench, depending on the decisions made by our governments, communities, and schools. The voices of African Americans heard in this book bring home for the reader the everyday impact of national policy issues and debates on race and class in America.
Opportunity and uncertainty Anisef, Paul
Opportunity and uncertainty,
c2000, 2000, 20001010, 2000-01-01
eBook, Book
Based on the longest-running survey of its kind in Canada, this book examines events in the lives of a generation of Ontario residents who graduated from grade 12 in 1973 and recreates the world in ...which these high school students faced the future.
