Obesity is a complex disease that is regulated by both central and peripheral mechanisms. New medicines for the treatment and prevention of obesity will need to overcome the powerful compensatory ...responses of the overlapping, and often redundant, networks that have evolved to safeguard efficient energy use. Despite great progress in the identification of central signals that regulate satiety, and considerable investment in the development of appetite-controlling medications, success has been modest so far. Here we review the main enzymes that are involved in different stages of lipid metabolism -- from digestion and absorption through synthesis and storage to mobilization and oxidation -- which might be successfully targeted by new pharmacotherapies.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The combination of drugged and drunk driving is an important policy topic as some states and countries have liberalized prohibitions on substance use to varying degrees. In this study, we analyze the ...effect of legal access to alcohol on suspected drug impaired accidents. We find that accidents with suspected drug impairment significantly increase when a driver gains legal access to alcohol at age 21. Our findings suggest that even if alcohol and drug consumption are substitutes, as much of the literature suggests, potential interactive effects may offset the reduction in decreased alcohol consumption from drugs.
Highly active antiretroviral therapy (HAART) based on combinations of drugs that target key enzymes in the life-cycle of human immunodeficiency virus (HIV) has considerably reduced morbidity and ...mortality from HIV infection since its introduction in the mid-1990s. However, the growing problem of the emergence of HIV strains that are resistant not only to individual drugs, but to whole drug classes, means that agents with new mechanisms of action are needed. Here, we describe the discovery and development of enfuvirtide (Fuzeon), the first drug to inhibit the entry of HIV-1 into host cells.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Drug development is a risky business. Success or failure often depends on selecting one or two molecules for development from many choices offered by the engines of high-throughput discovery. A lead ...candidate needs to possess adequate bioactivity, appropriate physical-chemical properties to enable formulation development, the ability to cross crucial membranes, reasonable metabolic stability and appropriate safety and efficacy in humans. Predicting how a drug will behave in humans before clinical testing requires a battery of sophisticated in vitro tests that complement traditional in vivo animal safety assessments. This review discusses how to strategically identify which non-clinical studies should be performed to provide the required guidance and comfort to stakeholders involved in clinical drug testing.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
This powerful work of gonzo journalism, predating the widespread acknowledgement of the opioid epidemic as such, immerses the reader in the world of homelessness and drug and alcohol abuse in the ...contemporary United States. For over a decade Philippe Bourgois and Jeff Schonberg followed a social network of two dozen heroin injectors and crack smokers in the San Francisco drug scene, accompanying them as they scrambled to generate income through burglary, larceny, panhandling, recycling, and day labor. Righteous Dopefiend interweaves stunning black-and-white photography with vivid dialogue, oral biography, detailed field notes, and critical theoretical analysis to viscerally illustrate the life of a drug addict. Its gripping narrative develops a cast of characters around the themes of violence, racism and race relations, sexuality, trauma, embodied suffering, social inequality, and power relations. The result is a dispassionate chronicle of fixes and overdoses; of survival, loss, caring, and hope rooted in the drug abusers' determination to hang on for one more day, through a "moral economy of sharing" that precariously balances mutual solidarity and interpersonal betrayal.
Nastavno prethodnim radovima u koji- ma su opisana otrovanja pasa i mačaka hranom i dodatcima hrani: čokoladom, kavom, grožđem, lukom i oraščićima makadamije te ksilitolom i solju u ovom su radu ...opisana otrovanja sredstvima koja izazivaju ovisnost odnosno nekim depresorima središnjeg živčanog sustava: marihuanom, opioidima, „klupskim“ drogama flunitrazepam i gamahidroksibutirat (GHB). Ilegalni lijekovi ili zloporabne droge su vrlo čest uzrok otrovanja kućnih ljubimaca od kojih su psi najprijemljiviji. Otrovanje nastaje zbog slučajne ingestije, krivog doziranja, ali i zlonamjernih trovanja. Ingestija zloporabnih droga predstavlja dijagnostički, često i etički izazov veterinarima kliničarima, a vlasnici vrlo često nisu uopće svjesni čemu je životinja bila izložena. U ovom radu opisani su toksični učinci najčešćih depresora središnjeg živčanog sustava u kontekstu veterinarske toksikologije - izvori otrovanja, toksičnost, toksikokinetika, mehanizam toksičnog djelovanja, klinički znakovi otrovanja, dijagnostika i liječenje otrovanih životinja. Cilj ovog rada je detaljan opis najčešćih lijekova koji se zloupotrebljuju, klinički protokol te terapija otrovanih životinja u svrhu informiranja vlasnika životinja u smislu preventivnog djelovanja i izbjegavanja rizika kontakta životinja s navedenim lijekovima.
Following previous work in which we described poisoning with food and food additives: chocolate, coffee, grapes, macadamia nuts, onions and garlic, xylitol and salt this paper described the poisoning with the most common central nervous system depressants (marijuana, barbiturates, opioids, “club” drugs-flunitrazepam and Gamma hydroxy- butyrate (GHB)). Exposure to illegal drugs is very common cause of companion animal poi- soning, of which dogs are the most susceptible. The poisoning is due to accidental ingestion, wrong dosage, but also malicious poisoning. Illegal drug ingestion presents both diagnostic and ethical challenge to the clinician and pet owners may not be aware of what the animal was exposed to. This work describes the most common central nervous system depressants in context of veterinary toxicology - sources of poisoning, toxicity, toxicokinetic, mechanism of action-clinical signs of poisoning, diagnostics and treatment of poisoned animals. The aim of this thesis is a detailed description of the most commonly used drugs, clinical protocol and treatment of poisoned animals in order to raise awareness for animal owners in terms of preventive action and avoiding the risk of animal contact with these drugs.
The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for ...dealing with the growing body of information from structural genomics.
Advanced methods for incorporating protein flexibility into database searching and computer-aided drug design are not only needed to obtain proper results; they are critical for dealing with the growing body of information from structural genomics.
Metabolic engineering has been defined as the redirection of metabolic pathways using genetic manipulation. Since the emergence of metabolic engineering science in the early 1980s, the field has made ...notable strides not only at a conceptual level, but also with regard to translating these concepts into practical products and processes. Today, metabolic engineering plays an important role in the generation of fuels from renewable resources, the conversion of agricultural raw materials (for example, corn syrup) into bulk and specialty chemicals, and the discovery, development and scale-up of therapeutically useful products. This article focuses on recent advances in the last category. Specifically, we review the impact that converging developments in genetic engineering and biosynthetic chemistry are having on natural-product drug discovery.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
60.
Drugging France Black, Sara E
2022, 2022-09-15, Letnik:
5
eBook
Nineteenth-century drug consumption permeated French society and encouraged the chemical enhancement of modern life. Drugging France highlights the medical histories of these drugs, chronicling how ...doctors transformed exotic botanicals and unpredictable chemicals into substances that reconfigured how people experienced their minds and bodies.
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