Adding to research on internet memes and humor, this study examines a set of image macros related to a specific viral media event (i.e., “cash me ousside”). This particular meme is linked to a ...popular catchphrase uttered by a young teenage girl, who appeared on a 2016 episode of the U.S. television talk show, Dr. Phil. We compiled a dataset of 220 image macros related to this media event from three online platforms. Our analysis focuses on various forms of linguistic humor, which most often rely on multimodal interactions between textual and visual elements. Our findings reveal multiple instances of wordplay involving paronymy as well as register-based humor and humor involving the voicing of recognizable figures. In addition, multimodal play often involves semiotic blends of this particular meme with other popular memes. Overall, our study illustrates unique combinations of unexpected elements and semiotic extensions of a non-standard catchphrase with other visual images, thereby establishing incongruity and generating humorous meanings.
•Creative mechanisms of linguistic humor in internet memes may involve wordplay and shifts in linguistic register or style.•Creative humor involves interactions between textual or visual components of memes along with other user-generated content.•Image macros exhibit unique multimodal juxtapositions extending the prototypical text-image structure.•Multiple layers of meaning are embedded in memes and their interpretation depends on advanced inferential strategies.
Characterized by optic nerve atrophy due to retinal ganglion cell (RGC) death, glaucoma is the leading cause of irreversible blindness worldwide. Of the major risk factors for glaucoma (age, ocular ...hypertension, and genetics), only elevated intraocular pressure (IOP) is modifiable, which is largely regulated by aqueous humor outflow through the trabecular meshwork. Glucocorticoids such as dexamethasone have long been known to elevate IOP and lead to glaucoma. However, several recent studies have reported that steroid hormone estrogen levels inversely correlate with glaucoma risk, and that variants in estrogen signaling genes have been associated with glaucoma. As a result, estrogen dysregulation may contribute to glaucoma pathogenesis, and estrogen signaling may protect against glaucoma. The mechanism for estrogen-related protection against glaucoma is not completely understood but likely involves both regulation of IOP homeostasis and neuroprotection of RGCs. Based upon its known activities, estrogen signaling may promote IOP homeostasis by affecting extracellular matrix turnover, focal adhesion assembly, actin stress fiber formation, mechanosensation, and nitric oxide production. In addition, estrogen receptors in the RGCs may mediate neuroprotective functions. As a result, the estrogen signaling pathway may offer a therapeutic target for both IOP control and neuroprotection. This review examines the evidence for a relationship between estrogen and IOP and explores the possible mechanisms by which estrogen maintains IOP homeostasis.
This study investigated the content of inflammatory cytokines and oxidative stress levels in the aqueous humor (AH) of patients with high myopia (HM) and explored the relationship between these ...factors and the axial length (AL) of the eye, to explore the roles of mild intraocular inflammation and oxidative stress imbalance in the occurrence and development of myopia. AH samples from 40 patients (70 eyes) were collected during implantable collamer lens (ICL-V4c) surgery. The subjects were divided into three groups according to AL: group A (AL ≤ 26 mm), group B (26 < AL ≤ 28 mm), and group C (AL ≥ 28 mm). The concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), and interleukin-1β (IL-1β) in the AH of the three groups were measured using the Luminex system. Oxidative stress levels were measured using reagent kits targeting total antioxidant capacity (T-AOC), catalase (CAT), and nitric oxide (NO) and malonaldehyde (MDA) content. The results showed compared with group A, IL-1β, MMP-2, and IL-6 concentrations were significantly higher and T-AOC levels were significantly lower in group C. There were no significant differences in CAT, NO, MDA, or TNF-α levels among the groups. The concentrations of IL-6 (r = 0.379, p = 0.016), MMP-2 (r = 0.469, p = 0.002), and MDA (r = 0.354, p = 0.025) in AH were positively correlated with the AL, whereas T-AOC (r = -0.678, p = 0.000) was negatively correlated with AL. These results suggest that mild intraocular inflammation and oxidative stress imbalance may be associated with myopia. Further experiments are needed to confirm the role of mild intraocular inflammation and oxidative stress imbalance in the occurrence and development of myopia.
•This study tested the two-step model of humor comprehension via EEG measures.•The incongruity detection step affects the Left Anterior Negativity and not the N400.•The resolution step involves the ...late LAN and the P600 extending in a later phase.•The later stage affects the LPC and possibly reflects more elaborative inferences.•Participant-based and item-based differences were observed in early LAN and P600.
We studied the electrophysiological correlates of verbal humor comprehension by comparing Event Related Potentials (ERPs) and time-frequency representations recorded while 50 participants read humorous and non-humorous passages. Using linear mixed models on single trials we showed that humorous target words elicited a larger Left Anterior Negativity (LAN), sustained in time and followed by a positive shift involving P600 and Late Positive Complex (LPC) components. In the time-frequency domain, humor was associated with a power decrease in the beta-band of the EEG. Furthermore, participants’ Autism-spectrum Quotient correlated with the size of the LAN, suggesting that social skills may affect humor comprehension during the early processing phase. Our results describe a sequence of events where incongruity detection (associated with the LAN) precedes a composite set of mechanisms serving resolution and acting in parallel: the sustained LAN might reflect the search for an alternative script, while the P600 might index inferential processes arriving at the resolution and the updating of the discourse model. The processing differences associated with the LPC and the changes in beta power may reflect a later stage of more elaborative and reflective processing (where the receiver reflects upon the joke’s solution) and the abandonment of the current discourse model.
Conspiracy theories have accompanied vaccination since its mass introduction, circulating, among other forms, in humour – such as cartoons, and now, memes. Importantly, humour has targeted both ...vaccination and anti-vaccination stances. In this study, we discuss the peculiarities of humorous content within the vaccination debate and uncover the most popular thematic categories, forms and logical mechanisms of humour. We show that humorous and serious discussions on vaccination go hand-in-hand, but playfulness and ambiguity of humour complicate public understanding of the vaccination debate. Our analysis shows that vaccination humour often simplifies the complex issue of vaccination and makes it more understandable and more tangible for a broad audience.
This study investigated relational uncertainty as a mechanism through which perceived partner humor use affects recipient’s relationship satisfaction. Two hundred individuals completed measures of ...their partners’ perceived positive and negative humor use, their relational uncertainty and relationship satisfaction. Results reveal that perceived partner’s positive relational humor use predicted greater relationship satisfaction, and perceived partner’s negative relational humor use predicted diminished relationship satisfaction. Further, relational uncertainty mediated relationships between perceived partner positive humor and satisfaction and perceived partner negative humor and satisfaction.
In order to elucidate involvement of cyclic AMP and intracellular Ca2+,Ca2+i, in the modulation of aqueous humour formation (AHF), we studied the effects of terbutaline, forskolin and 8-Br-cAMP in ...the isolated bovine eye. We also studied the interaction of cAMP on calcium signaling in cultured ciliary epithelial (CE) cells. Drug effects on AHF were measured by fluorescein dilution. Drug effects on Ca2+i were studied by the fura-2 fluorescence ratio technique. Terbutaline (100 nmol-100 M), forskolin (30 nM-100 M) or 8-Br-cAMP (100 nM- 10 μM), administered in the arterial perfusate produced significant reductions in AHF. The AH reducing effect of terbutaline was blocked by a selective inhibitor of protein kinase A (KT-5720). ATP (100 M) caused a rapid, transient (peak) increase in Ca2+i followed by a sustained plateau phase lasting more than 5 minutes. Preincubation of the cells (6 min) with terbutaline, forskolin or 8-Br-cAMP significantly reduced the peak calcium response to ATP. The sustained plateau phase of the response, on the other hand, was augmented by each of the agents. KT-5720 partially reversed the inhibitory effect of terbutaline on the peak and totally inhibited its effect on the plateau phase. These data indicate: (a) that AHF in the bovine eye can be manipulated through cyclic AMP, operating via protein kinase A, (b) that protein kinase A can affect Ca2+i homeostasis, (c) that calcium release from the intracellular store, not the entry, affects AHF, and (d) that interaction of Ca2+i with cAMP plays a role in modulating AH secretion.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Understanding jokes may differ between mono- and bilinguals because of differences in lexical access; fluency and sense of humor may also be relevant. Three experiments examined English-language joke ...comprehension in monolingual (n = 91) and bilingual (n = 111) undergraduates, Russian–English bilinguals (n = 39), and MTurk monolinguals (n = 77). Participants rated jokes and non-jokes in English as funny or not funny. We assessed the effects of bilingualism, language dominance, fluency, sense of humor, experience, and motivation on response time (RT) and sensitivity (d′) in identifying jokes. Bilingualism predicted neither RT nor d′ in mono- and English-dominant bilingual undergraduates; English fluency predicted d′. Russians were slower than English-dominant bilinguals but were more not less sensitive to humor. MTurk monolinguals were faster than undergraduates and equally sensitive; sense of humor predicted sensitivity. Overall, humor processing is alternately affected by fluency, sense of humor, and motivation, depending on the population. Bilingualism per se is not a factor.
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