Spontaneous dissection of the abdominal aorta should be considered as a vascular surgical emergency. We report here our experience with this rare pathology.
At our hospital, we operated on 200 ...patients for abdominal aortic aneurysm over a 4-year period, and aortic dissection was the underlying pathology in eight of them. Diagnosis was based on history, imaging study findings and visualization at surgery.
The mean size of the aorta at the time of diagnosis was 5.5 +/- 0.4 cm. Aortic dissection was complicated by acute ischemia of lower limb and paraplegia in 1 patient and four patients were admitted to hospital with severe abdominal and back pain. Two patients with contained rupture were admitted with hemodynamic collapse and shock. One of the patients who presented with abdominal pain experienced also sudden onset paraplegia. The diagnosis of dissecting abdominal aortic aneurysm was established incidentally in the remaining 2 patients. All patients were treated using open techniques with paramedian transperitoneal incision. We performed aorto-bifemoral bypass operation procedure in all patients; there was no post-operative mortality in our series. One patient had to be reoperated because of bleeding during early postoperative period. One patient required transient dialysis at early postoperative period because of transient rise of serum creatinine level.
The surgical treatment of spontaneous abdominal aortic dissection is usually associated with low morbidity and mortality rates. However, the clinical form of presentation of acute abdominal aortic dissection is usually nonspecific, and diagnosis requires a high index of suspicion.
By improving short and long-term survivals, cardiac transplantation would be a more realistic curative treatment modality. The aim of this study was to evaluate factors associated with the long-term ...survival following cardiac transplantations in our center.
Forty-four patients were operated on cardiac transplantation between 1989 and November 2006. The study was designed in a retrospective manner and all data were collected from hospital records. Our study population consisted of 16 patients (Group A) who survived >1 month, but died <2 years after cardiac transplantation and 17 patients (Group B) who survived more than 2 years. All patients had triple immunosuppressive therapy (cyclosporine, azathioprine, corticosteroid). Statistical analyses were performed using Fischer's exact and Mann Whitney U tests, and multivariate regression analysis. Survival was analyzed using Cox proportional hazard regression analysis.
Group B patients had lower pre-transplant creatinine levels (0.93+/-0.28 mg/dl vs. 1.16+/-0.21 mg/dl, p=0.033) younger donor age (24.5+/-6.3 years vs. 30.1+/-8.1 years, p=0.017) and more male donors (82.3% vs. 50%, p=0.05) as compared with Group A patients. The perioperative and follow-up analysis showed that patients with long-term survival had shorter ischemic time (141.5+/-33.2 min vs. 182.5+/-49.2 min, p=0.007), aortic cross clamp time (65.9+/-10.2 min vs. 83.6+/-7.9 min, p<0.001), less amount of blood transfusion (3.4+/-1.6 units vs. 5.0+/-1.5 units, p=0.01), better NYHA status after operation (1+/-0 vs. 1.63+/-0.72, p=0.014) and less frequent acute rejection episodes (11.8% vs. 68.8%, p<0.001) than those with short-term survival after operation. Cox proportional hazard regression analysis showed higher preoperative creatinine level (HR=42.6, 95% CI 4.67-388.21, p=0.001), acute rejection (HR=4.45, 95% 1.44-13.77, p=0.01), early postoperative functional status (HR=4.84, 95% CI 1.9-12.27, p=0.001) and unsatisfactory rejection surveillance protocol in the first 6 months after transplantation (HR=0.2, 95% CI 0.07-0.67, p=0.008) were prominent factors associated with the long-term survival.
The availability of the donor hearts from younger male donors with the shortest ischemic times is identified as the most significant factor improving long-term survival. The main strategy in cardiac transplantation should be shortening ischemic times and applying strict postoperative follow-up.
The study compared ground red hot pepper agar (GRHP) and Guizotia abyssinica creatinine agar (GACA), a medium routinely used for isolation of Cryptococcus neoformans. In order to confirm the capacity ...of GRHP to support the Cr. neoformans growth and pigment production, 15 strains were inoculated onto GRHP and GACA. No significant differences in the growth and pigmentation of the tested strains on the two media were noted. As heavily contaminated specimens, 50 samples of pigeon droppings were examined by plating on GRHP and GACA, which resulted in the isolation of 14 and nine Cr. neoformans strains, respectively. The results indicate that GRHP, as a result of its superior selectivity and significant reduction of contaminant growth, provides better conditions than GACA for isolation and presumptive identification of Cr. neoformans from heavily contaminated specimens.
Zusammenfassung. In der Studie wurden Agar mit gemahlenem scharfem Paprika (GRHP‐Agar) und Guizotia abyssinica‐Kreatinin‐Agar (GACA), ein Medium, das routinemäßig für die Isolierung von Cryptococcus neoformans verwendet wird, verglichen. Um die Leistungsfähigkeit des GRHP‐Agars zu bestätigen, daß Wachstum und Pigmentbildung von Cr. neoformans gefördert werden, wurden 15 Stämme auf GRHP‐Agar und GACA angezüchtet. Es konnten keine Unterschiede in Wachstum und Pigmentierung der getesteten Stämme auf den beiden Medien beobachtet werden. Als stark kontaminierte Materialen wurden 50 Proben von Taubenexkrementen durch Inokulation auf GRHP‐Agar und GACA untersucht. Daraus resultierte die Isolierung von 14 bzw. 9 Stämmen von Cr. neoformans. Die Ergebnisse zeigen, daß GRHP‐Agar auf Grund seiner überlegenen Selektivität und signifikanten Reduktion des Wachstums von Kontaminanten, bessere Bedingungen als GACA für die Isolierung und präsumptive Identifizierung von Cr. neoformans aus stark kontaminierten Materialien bietet.
The aim of this study was to investigate the differences in spermatological and seminal plasma biochemical characteristics between normozoospermic and oligoasthenozoospermic bulls. A total of 8 bulls ...were used and they were divided into 4 groups: Holstein normozoospermic (HN) and oligoasthenozoospermic (HO), and Brown Swiss normozoospermic (BSN) and oligoasthenozoospermic (BSO). Spermatological parameters investigated included semen volume, color, concentration, motility, and percentage of abnormal sperm. Biochemical parameters measured in seminal plasma included pH, glucose, urea, creatinine, uric acid, cholesterol (CH), triglyceride, Mg, inorganic P (Pi), Ca, Na, K, and Cl ion concentrations. Colorimetric and ion selective electrode methods were used for these analyses. In general, Ca and Pi levels were lower in the oligoasthenozoospermic groups than in the normozoospermic groups of the 2 breeds. In Brown Swiss bulls, CH and triglyceride levels were higher in the BSN group than in the BSO group. In Holstein bulls, Na level was higher in the HO group than in the HN group. In contrast, K level was higher in the HN group than in the HO group. Negative correlations were found between abnormal spermatozoa morphology and mass activity, motility, sperm concentration, and CH, Pi, Ca, and Na concentrations; however, there was a positive correlation between abnormal spermatozoa morphology and K+ ion concentration.
Bu çalışmanın amacı, normozoospermic ve oligoasthenozoospermic boğalar arasındaki spermatolojik ve seminal plazma biyokimyasal özelliklerindeki farklılıkların incelenmesidir. Çalışmada toplam 8 baş boğa kullanıldı ve boğalar; Holştayn normozoospermik (HN) ve oligoasthenozoospermik (HO) ile Brown Swiss normozoospermik (BSN) and oligoasthenozoospermik (BSO) olmak üzere 4 gruba ayrıldı. Spermatolojik parametreler olarak hacim, renk, yoğunluk, motilite ve anormal spermatozoa oranı incelendi. Seminal plazma biyokimyasal parametrelerinden ise pH, glikoz, üre, kreatin, ürik asit, kolesterol, trigliserid, magnezyum, inorganik fosfor (Pi), kalsiyum, sodyum, potasyum ve klor iyon konsantrasyonları ölçüldü. Bu analizlerde Kolorimetri ve İyon Selektif Elektrot Metotları kullanıldı. Genellikle, Ca ve Pi seviyeleri her iki ırkın oligoasthenozoospermik gruplarında diğer gruba oranla daha düşük bulundu. Brown Swiss boğalarda CH ve trigliserid seviyeleri BSN grubunda, BSO grubuna göre daha yüksek bulundu. Holştayn boğalarda Na seviyesi HO grubunda HN grubuna göre daha yüksek bulundu. Buna karşılık, K iyonu düzeyi HN grubunda HO gruptan daha yüksek saptandı. Anormal spermatozoa morfolojisi ile mass aktivite, motilite, yoğunluk, CH, Pi, Ca ve Na konsantrasyonları arasında negatif korelasyonlar bulunurken, K konsantrasyonu ile anormal spermatozoa morfolojisi arasında pozitif korelasyon tespit edildi.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The objective of this experimental study was to examine the pathological effects of the intramuscular administration of gentamicin to growing chickens. Two experiments of 35 days´ duration were ...conducted simultaneously. In both experiments White Leghorn cockerels of 6 weeks of age were randomly divided into 4 groups and gentamicin was administered intramuscularly to the birds on days 1 and 3 at a dose of 10, 50, 100, and 0 mg/kg body weight, respectively. Birds administered 50 and 100 mg/kg gentamicin showed depression, diarrhea, increased water intake, and lower body weights. Mortality was 0%, 26%, and 100% in the 10, 50, and 100 mg/kg gentamicin groups, respectively. Kidneys and livers of the 50 and 100 mg/kg groups were swollen, friable, and hemorrhagic. Microscopically acute tubular necrosis was observed in the kidneys and fatty change of hepatocytes in the liver. Gentamicin administration resulted in a significant decrease in serum albumin and a significant increase in urea nitrogen and creatinine concentrations.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Bu çalışma Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerin belirlenmesi amacıyla yapılmıştır. ...Çalışma 3-6 yaşlı ve farklı cinsiyette toplam 30 sokak köpeği üzerinde yürütülmüştür. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte olduğu tespit edilen köpekler tedavi (n=18) ve pozitif kontrol (n=6) grubu olarak ayrılmış ve herhangi bir helmint enfeksiyonu tespit edilmeyen köpekler negatif kontrol (n=6) grubu olarak kullanılmıştır. Tedavi grubundaki köpeklere Eprinomectin 100 pg/kg oral uygulanmış, negatif ve pozitif kontrol gruplarındaki köpeklere herhangi bir ilaç uygulaması yapılmamıştır. Tüm gruplardan tedavi öncesinden başlanarak tedavi sonrası 7. ve 15. günlerde kan ve dışkı örnekleri düzenli olarak alınmıştır. Tam kan indirgenmiş glutasyon (GSH), plazma malondialdehit (MDA), antioksidan aktivite (AOA), glikoz, total protein, üre, kreatinin, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), gama-glutamil transferaz (GGT) düzeyleri ile enfekte köpeklere gram dışkı yumurta sayımı (EPG) yapılarak enfeksiyon şiddeti belirlenmiştir. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte köpeklerde kreatinin ve lipid peroksidasyonu artarken, total protein ve antioksidan aktivitenin düştüğü ve bu helmintlerin uygun bir antelmentikle tedavi edilmesinin, oluşan oksidatif hasarı hafifletmede etkili olduğu tespit edilmiştir.
Using serum cystatin C in estimating glomerular filtration rate (GFR) has in recent times been recommended. A number of simple formulas for calculating GFR have been derived specifically from serum ...cystatin C concentrations. The purpose of this study was to assess the significance of cystatin C and of the two most frequently applied of these formulas in estimating glomerular filtration rate compared to serum creatinine and its derived formulas for estimating glomerular filtration rate from creatinine concentrations. The study included 74 patients: 59 were in various stages of chronic renal insufficiency (divided into two subgroups: I with GFR ≥ 60 mL/min/1.73m2 and II with GFR<60 mL/min/1.73m2) and 15 on hemodialysis. A control group of 30 healthy participants was also included in the study. Serum values of cystatin C ranged from: 0.86 ± 0.16 mg/L in subgroup I, and 1.77 ± 0.79 mg/L in subgroup II, to 6.9 ± 1.83 mg/L in patients on hemodialysis. The correlation between the two formulas derived from cystatin C and the clearance of creatinine, as well as the Cockcroft and Gault's formula, was significant, while one of the formulas derived from cystatin C did not show a significant correlation with MDRD. It was concluded that serum cystatin C is a significant marker in estimating glomerular filtration rate, especially in the advanced stages of chronic renal insufficiency.
U novije vreme preporučena je upotreba serumskog cistatina C u proceni jačine glomerulske filtracije (GFR). Upravo iz serumske koncentracije cistatina C je izvedeno nekoliko jednostavnih formula za izračunavanje GFR. Cilj ove studije je bio da proceni značaj cistatina C i dve najčešće primenjivane od tih formula u proceni jačine glomerulske filtracije u poređenju sa serumskim kreatininom i izvedenim formulama za procenu jačine glomerulske filtracije iz koncentracija kreatinina. U studiju je uključeno 74 ispitanika: 59 u različitim stadijumima hronične bubrežne insuficijencije (podeljenih u dve podgrupe: I sa GFR ≥ 60 mL/min/1,73m2 i II sa GFR< 60 mL/min/1,73m2) i 15 na hemodijalizi. U studiju je bila uključena i kontrolna grupa od 30 zdravih ispitanika. Serumske vrednosti cistatina C su se kretale: u podgrupi I 0,86 ± 0,16 mg/L, u podgrupi II 1,77 ± 0,79 mg/L i kod ispitanika na hemodijalizi 6,9 ± 1,83 mg/L. Korelacija između obe formule izvedene iz cistatina C i klirensa kreatinina kao i Kokroft-Gaultove formule bila je značajna, dok jedna od ovih formuli izvedenih iz cistatina C nije pokazala značajnu korelaciju sa MDRD. Može se zaključiti da je serumski cistatin C značajan parametar u proceni jačine glomerulske filtracije, naročito u odmaklim stadijumima hronične bubrežne insuficijencije.
Haemato-biochemical aspects of Parturient Haemoglobinuria in Buffalo Akhtar, M.Z., University of Agriculture, Faculty of Veterinary Science, Faisalabad (Pakistan). Div. of Veterinary Pathology; Khan, A., University of Agriculture, Faculty of Veterinary Science, Faisalabad (Pakistan). Div. of Veterinary Pathology; Khan, M.Z., University of Agriculture, Faculty of Veterinary Science, Faisalabad (Pakistan). Div. of Veterinary Pathology ...
Turkish journal of veterinary & animal sciences,
01/2007, Letnik:
31, Številka:
2
Journal Article
Recenzirano
Odprti dostop
This study aimed to determine the haematological and biochemical changes that occur in buffaloes with parturient haemoglobinuria (PHU). For this purpose, serum samples from 60 PHU-affected and 60 ...apparently healthy buffaloes were collected and analysed. Mean erythrocyte count (3.6 ± 1.0 1012/l), haemoglobin concentration (5.8 ± 1.4 g/dl), and haematocrit (16.9 ± 2.8 %) of the PHU-affected buffaloes were lower (P<0.001), while their erythrocyte sedimentation rate (104.1 ± 36.2 mm/h) was higher (P<0.001) in comparison to the healthy buffaloes. Neutrophils (43.0 ± 4.5%), urea (49.7 ± 7.8 mg/dl) and creatinine (2.1 ± 0.4 mg/dl) concentrations were significantly higher in the PHU-affected buffaloes, while lymphocytes (48.7 ± 2.9%) and erythrocytic glucose-6-phosphate dehydrogenase (G6PD) (92.3 ± 13.2 mU/109 TECs) were lower than in the healthy buffaloes. Serum phosphorus (1.9 ± 0.6 mg/dl) and copper (65.4 ± 6.0 µg/dl) were lower (P<0.001), while molybdenum (171.5 ± 56.7 µg/dl) was higher in the PHU-affected buffaloes as compared to those values in the healthy buffaloes. It was concluded that PHUaffected buffaloes usually suffer from severe anaemia and hypophosphataemia, and erythrocytes with significantly reduced G6PD are prone to haemolysis, leading to haemoglobinuria in buffaloes.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Transplantacija bubrega značajno poboljšava kvalitetu, ali i očekivano trajanje života bolesnika. Veliki nesrazmjer između broja dostupnih i potrebnih organa produljuje vrijeme čekanja na ...transplantaciju. Visoka smrtnost u populaciji bolesnika na hemodijalizi uz prihvatljive ishode transplantacije bubrega od darovatelja po proširenim kriterijima rezultirali su sve češćim transplantacijama organa od starijih darovatelja. Prikazujemo slučaj transplantacije bubrega 83-godišnjeg darovatelja primatelju starom 72 godine. Odgovarajuća priprema darovatelja nakon moždane smrti u jedinici intenzivnog liječenja, preimplantacijska biopsija i kratko vrijeme hladne ishemije bili su ključ za procjenu prihvaćanja organa za transplantaciju i rezultirali su primarnom funkcijom presatka. Primatelj starije životne dobi bez značajnijih pridruženih bolesti, kratko liječenje dijalizom uz odgovarajuće postoperativno praćenje bolesnika i imunosupresivne terapije rezultirali su brzim oporavkom bolesnika bez intraoperativnih i ranih postoperativnih komplikacija te kratkim trajanjem hospitalizacije.
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