The aim of this study was to assess the superiority of ICG-99mTc-nanocolloid for the intraoperative visual detection of sentinel lymph nodes (SLNs) in vulvar squamous cell carcinoma (VSCC) patients ...compared to standard SLN detection using 99mTc-nanocolloid with blue dye.
In this multicenter, randomized controlled trial, VSCC patients underwent either the standard SLN procedure or with the hybrid tracer ICG-99mTc-nanocolloid. The primary endpoint was the percentage of fluorescent SLNs compared to blue SLNs. Secondary endpoints were successful SLN procedures, surgical outcomes and postoperative complications.
Forty-eight patients were randomized to the standard (n = 24) or fluorescence imaging group (n = 24) using ICG-99mTc-nanocolloid. The percentage of blue SLNs was 65.3% compared to 92.5% fluorescent SLNs (p < 0.001). A successful SLN procedure was obtained in 92.1% of the groins in the standard group and 97.2% of the groins in the fluorescence imaging group (p = 0.33). Groups did not differ in surgical outcome, although more short-term postoperative complications were documented in the standard group (p = 0.041).
Intraoperative visual detection of SLNs in patients with VSCC using ICG-99mTc-nanocolloid was superior compared to 99mTc-nanocolloid and blue dye. The rate of successful SLN procedures between both groups was not significantly different. Fluorescence imaging has potential to be used routinely in the SLN procedure in VSCC patients to facilitate the search by direct visualization.
Clinical Trial Registration: Netherlands Trial Register (Trial ID NL7443).
Soil nanocolloids are highly mobile and can act as carriers for the transport of antibiotics to a wider and deeper range of soils; however, the inherent behavior and mechanism of nanocolloid-carrying ...antibiotics in soil remain unclear. In this study, we conducted a comprehensive investigation of the migration of antibiotics in paddy red soil during the organic fertilization process using four common soil nanocolloids: kaolin (KL), montmorillonite (MT), hematite (HT), and humic acid (HA). The results showed that nanocolloid carriers promoted the intra-medium (from soil surface to the bottom) and inter-medium transfer (from organic fertilizers to soil) of antibiotics. The migration mechanisms of antibiotics carried by the nanocolloids differed: the phenolic hydroxyl and carboxyl groups of HA esterified with the carboxyl groups of quinolones and phenolic hydroxyl groups of tetracyclines, respectively, while the oxygen atoms of HT formed stabilizing complexes with the soil, which could further adsorb antibiotics using their functional group-rich complexes. Smaller antibiotic compounds were adsorbed in the metal oxide interlayer of MT via cation exchange, whereas KL adsorbed antibiotics on its metal oxide surface layer in the same way but were susceptible to desorption. Additionally, nanocolloids changed the adsorption capacity of soil for antibiotics and influenced the enrichment of dominant/functional bacteria (e.g., Burkholderiaceae) and thus varied the vertical distribution of antibiotics in soil. These findings enhance our understanding of the migration behavior and mechanism of nanocolloid-carrying antibiotics in red paddy soil and provide a theoretical foundation for preventing and controlling antibiotic pollution in arable systems.
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•Bio-safe ligand-free and easily dispersible ZnO QDs were prepared by a novel organometallic strategy.•The process involves transformation of a DMSO solution of Et2Zn upon air ...exposition.•DMSO acts both as a solvent and a low-molecular-weight l-type surface protector.•The resulting QDs display unique long-term colloidal stability.•The developed method leads to the rational-by-design ZnO-based functional materials.
Colloidal quantum dots (QDs) are of widespread importance for their unique combination of physicochemical properties and a number of prospective applications, and the search for efficient synthetic methods to produce readily dispersible, functionally stable and ligand-free quantum dot-based inks is a vital and timely area of research. We describe a convenient room-temperature and non-external-surfactant-assisted organometallic synthetic strategy for the reproducible preparation of solution-processable organic ligand-free zinc oxide (ZnO) QDs. The process involves the controlled transformation of a DMSO solution of commercially available diethylzinc upon exposition towards atmospheric air, where H2O and O2 act simultaneously as oxygen sources, and DMSO acts both as a solvent and a low-molecular-weight l-type surface protector. The resulting QDs with a narrow size distribution (4.7 ± 0.8 nm) were comprehensively characterized with a combination of various analytical techniques, which nicely documented their unique stabilities when dried, precipitated, re-dissolved or exposed to air. Moreover, to substantiate idealized surface passivation of the resulting QDs, we investigated their stability in the biological environment and nano-specific activity toward selected normal and cancer cell lines, and no significant toxic effect was revealed. Undoubtedly, the reported one-step-one-pot organometallic approach paves the way to high-quality and bio-stable ZnO QDs coated by an easily and reversibly removable organic shell, auguring applications in a vast array of devices and nanomedicine.
Using sugar molecules as lyophilization protectants in HSA nanocolloid kit formulations is critical to obtaining kits with excellent stability. A thermal gelation method with no sugar treatment and ...variations in sugar (glucose, maltose, and lactose) was applied to produce these kits. The particle size and radiochemical purity results showed that HSA nanocolloid kits with sugar excipients are more stable than those without sugar. The addition of lactose as an excipient (HSA: lactose 1:10) results in a stable nanocolloid system, allowing for the development of novel lyophilized HSA nanocolloid kit formulations.
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•The water-soluble IR783 molecules can collaborate with the hydrophobic curcumin (Cur) to form carrier-free nanodrug delivery system via π-π stacking.•The yielded nanodrug delivery ...system exhibited efficient near-infrared fluorescence imaging on tumor and enhanced chemo-photothermal anti-tumor synergistic effect in vivo.•The carrier-free nanodrug delivery system had excellent biocompatibility and blood safety.
Carrier-free nanomedicine represents a new opportunity of using less inert materials for efficient drug delivery. To date, most reported carrier-free nanomedicine systems rely heavily on π-π stacking interaction between hydrophobic drugs. This work found that the hydrophilic IR783 dye can collaborate with the hydrophobic curcumin (Cur) compound to form a novel Cur@IR783 nanocolloid (NC) via self-assembly. The self-assembly of the hydrophilic IR783 and hydrophobic Cur improved the water dispersity of Cur, significantly facilitating its administration in vivo. Moreover, Cur@IR783 NC retained the IR783 properties of NIR fluorescence and photothermal conversion efficiency. Fluorescence imaging demonstrated that Cur@IR783 NC accumulated at the tumor site via the enhanced permeation and retention effect, which ensured enhanced anti-tumor effect. In vitro and in vivo experiments showed that the Cur@IR783 NC with laser irradiation yielded the most potent antitumor effect, and Cur@IR783 NC exhibited high biocompatibility. Overall, Cur@IR783 NC showed remarkable synergistic antitumor activity via chemo-photothermal combination therapy, providing a new promising approach for Cur-based applications in cancer treatment.
This paper outlines and discusses the thermal conductivity of 1-Butyl-3-methylimidazolium tetrafluoroborate ionic liquid, as well as three classes of nanocolloids. The C4mimBF4 ionic liquid was ...enhanced with three kinds of nanoparticles, Al2O3, ZnO and MWCNT and all fluids thermal conductivity was experimentally measured. Results discussion includes also an in-depth analysis on Prandtl number and thermal diffusivity. All the data were carefully debated in terms of state of the art advancement and these suspensions suitability for practical applications in heat transfer. It was found that the thermal conductivity increases with nanoparticles addition and this enhancement depends on nanoparticle type and temperature. Plus, the temperature influence is rather limited, while the consideration on Prandtl number and thermal diffusivity revealed that it is extremely relevant to consider all the thermophysical properties when choosing a new thermal fluid. Additionally, a comparison with well known correlations was inserted, concluding that no theory can estimate the ionic liquids nanocolloids thermal conductivity. Concluding, the thermal properties of C4mimBF4 ionic liquid and its nanocolloids with Al2O3, ZnO and MWCNT shows that these nanocolloids uncover great potential for heat transfer applications.
•1-Butyl-3-methylimidazolium tetrafluoroborate thermal conductivity is experimental determined.•The thermal conductivity of nanocolloids is debated in terms of nanoparticle mass fraction and temperature.•Thermal conductivity correlations are anticipated for C4mimBF4 and its nanocolloids.•The thermal diffusivity and Pr number of nanocolloids based on C4mimBF4 follow an in depth discussion.
Conductive inks allow for low cost and scalable deposition of conductive tracks and patterns for printed electronics. Metal nanoparticle colloids are a novel form for producing conductive inks. Laser ...Ablation Synthesis in Solution (LASiS) is a “green” method for the production of metal nanoparticle colloids without the need for environmentally hazardous chemicals, however the method has typically been limited by its low production rates. This study reports on the generation of an additive free silver nanocolloid with maximized productivity using a flow-based LASiS system and its characterization using dynamic light scattering, UV–VIS, transmission electron microscopy and field emission scanning electron microscopy. The productivity of the LASiS silver nanoparticle (size ∼34 ± 5 nm) was ∼0.9 mg mL−1. While the flow-based system achieves high laser ablation rates in the mass of nanomaterial generated per unit time, the volume of liquid required for the flow leads to relatively low concentrations. Therefore, in this work, LASiS concentrated ink was formulated via a centrifugal method, which was then drop-cast and heat treated to produce a conductive silver layer. Centrifuging to concentrate the ink was shown to be a necessary step to achieve good results, with the lowest resistance across the drop-cast material of 60.2 Ω after annealing.
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Front Cover: A multicomponent polymer is synthesized by CVD copolymerization to enable surface modification of a biointerface or nanoscale interface with multifunctional accessibility in NHS ...ester‐amine conjugation and photo‐initiated benzophenone crosslinking reactions. This is reported by Ruei‐Hung Yuan, Chih‐Yu Wu, Hsing‐Ying Tung, Hung‐Pin Hsieh, Yi‐Jye Li, Yu‐Chih Chiang and Hsien‐Yeh Chen, article number 1600322.
The efficacy of dynamic therapy for solid tumors suffers daunting challenges induced by tumor hypoxia. Herein, we report a biocompatible nanosystem containing Fe(OH)3-modified upconversion ...nanoparticles (UCNPs) for promoting synergetic chemo- and photodynamic therapy with the modulation of tumor hypoxia. In this system, UCNPs convert 808 nm near-infrared excitation to visible photon energy, which stimulates chlorin-e6 photosensitizers to generate toxic reactive oxygen species (ROS) by consumption of dissolved oxygen in cancer cells. Importantly, we employ Fe(OH)3 compounds to enable continuous oxygen generation in cancer cells and, meanwhile, induce extra ROS formation through the Fenton-like reaction. The system consequently improves the tumor treatment efficacy in vitro and in vivo. This study puts forward a novel combinatorial therapeutic platform for tumor microenvironment modulation and enhanced cancer therapy.
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