The Orbit of the Moon Contreras, Jose Utreras
American scientist,
05/2023, Letnik:
111, Številka:
3
Journal Article
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
14.
Divining Nature Cuille, Tili Boon
2021, 2020, 2020-12-15
eBook
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The Enlightenment remains widely associated with the rise of scientific progress and the loss of religious faith, a dual tendency that is thought to have contributed to the disenchantment of the ...world. In her wide-ranging and richly illustrated book, Tili Boon Cuillé questions the accuracy of this narrative by investigating the fate of the marvelous in the age of reason. Exploring the affinities between the natural sciences and the fine arts, Cuillé examines the representation of natural phenomena—whether harmonious or discordant—in natural history, painting, opera, and the novel from Buffon and Rameau to Ossian and Staël. She demonstrates that philosophical, artistic, and emotional responses to the ""spectacle of nature"" in eighteenth-century France included wonder, enthusiasm, melancholy, and the ""sentiment of divinity."" These ""passions of the soul,"" traditionally associated with religion and considered antithetical to enlightenment, were linked to the faculties of reason, imagination, and memory that structured Diderot's Encyclopédie and to contemporary theorizations of the sublime. As Cuillé reveals, the marvelous was not eradicated but instead preserved through the establishment and reform of major French cultural institutions dedicated to science, art, religion, and folklore that were designed to inform, enchant, and persuade. This book has been made possible in part by the National Endowment for the Humanities: Exploring the human endeavor.
Abstract
Objective
To examine the impact of autoimmune disease on the composite outcome of intensive care unit admission, intubation, or death, from COVID-19 in hospitalized patients.
Methods
...Retrospective cohort study of 186 patients hospitalized with COVID-19 between March 1st–April 15th, 2020 at New York-Presbyterian Hospital/Columbia University Irving Medical Center. The cohort included 62 patients with autoimmune disease and 124 age- and sex- matched controls. The primary outcome was a composite of intensive care unit admission, intubation, and death, with secondary outcome assessing time to in-hospital death. Baseline demographics, comorbidities, medications, vital signs, and laboratory values were collected. Conditional logistic regression and Cox proportional hazards regression were used to assess the association between autoimmune disease and clinical outcomes.
Results
Patients with autoimmune disease were more likely to have at least one comorbidity (25.8% vs. 12.9%, p=0.03), take chronic immunosuppressive medications (66.1% vs. 4.0%, p<0.01), and have had a solid organ transplant (16.1% vs. 1.6%, p<0.01). There were no significant differences in intensive care unit admission (14.2% vs. 19.4%, p=0.44), intubation (14.2% vs. 17.7%, p=0.62) or death (17.5% vs. 14.5%, p=0.77). On multivariable analysis, patients with autoimmune disease were not at an increased risk for a composite outcome of intensive care unit admission, intubation, or death (adjOR 0.79, 95%CI 0.37–1.67). On Cox regression, autoimmune disease was not associated with in-hospital mortality (adjHR 0.73, 95%CI 0.33–1.63).
Conclusion
Among patients hospitalized with COVID-19, individuals with autoimmune disease did not have an increased risk of a composite outcome of intensive care unit admission, intubation, or death.
Kaplan-Meier curve examining death, stratified by the presence or absence of autoimmune disease in all 186 patients, with 16 patients censored as of 4/29/2020
Abstract
Background
As the Coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to evolve, its influence on specific ...patient populations suffering from chronic disorders becomes increasingly important. Patients with inflammatory bowel disease (IBD) are commonly immunosuppressed with immunomodulators, biologics, and steroids. Therefore, IBD patients have been considered as a risk population for COVID-19. Yet, emerging epidemiologic data may indicate otherwise. It is still unclear, however, how COVID-19 infection affects IBD patients and how seroconversion against the virus might take place depending upon disease states and treatments. We describe a single center cohort of pediatric IBD patients with COVID-19, a subset of whom were tested for seroconversion subsequent to the laboratory test supported infection.
Methods and Results
The electronic medical records of pediatric IBD patients who tested positive for SARS-CoV-2 by nasopharyngeal swab based PCR testing were included in the study. The clinical course of IBD, concurrent medications, COVID-19 related symptoms, SARS-CoV-2 testing date, and SARS-CoV-2 IgG antibody testing date and result were examined.
A total of 13 pediatric IBD patients at Texas Children’s Hospital tested positive for SARS-CoV-2. Patient demographics and specifics of IBD disease and management are detailed in table 1. Management was not altered in any of these patients in response to the positive COVID-19 test. Seven (53.8%) had symptoms including fever, sore throat, fatigue, loss of taste, dizziness, loss of smell, abdominal pain, and/or diarrhea; six (46.2%) were asymptomatic. No patients required hospitalization attributed to COVID-19. Of the 13 patients, 6 (46.2%) have been already tested for seroconversion. Four (67.7%) had elevated SARS-CoV-2 IgG of whom 3 patients (50%) had acute and resolved symptoms; one (16.7%) had an ambiguous serology (reactive total IgG and IgM but negative IgG and IgM individually), and one (16.7%) had nonreactive antibody titers. Seroconversion was tested between 0.4, or 4 to 13.7 weeks after initial positive SARS-CoV-2 PCR testing. The close antibody testing at 0.4 weeks had the ambiguous results. Serologic testing for the additional cases is pending.
Conclusions
We describe a cohort of pediatric IBD patients with COVID-19 ranging from 1 week to 4 months after infection whose disease course has not been significantly affected. A large proportion of patients tested for seroconversion were found to mount a detectable IgG based immune response in spite of their medical immunosuppression. More research needs to be performed to evaluate the importance of seroconversion with relation to disease course andCOVID-19 reinfection in pediatric IBD patients.
The South Mountain Batholith (SMB; Nova Scotia, Canada) is the largest composite batholith exposed in the Appalachians and lies entirely within the most outboard Meguma terrane. In situ and CA-TIMS ...U-Pb dating and in situ isotopes (Lu-Hf, O) and geochemistry for zircon from all phases of the SMB constrain its source as well as its evolution. CA-ID-TIMS for zircon yields emplacement (autocryst) ages, indicating a transition from granodiorite (378.7 + or - 1.2 to 375.4 + or - 0.8 Ma) to leucogranite (375.4 to 371.8 + or - 0.8 Ma) over several million years. Furthermore, in situ SHRIMP, LA-MC-ICP-MS, and SIMS analyses of distinct zircon domains reveal: (1) abundant ancient xenocrysts (~420 Ma to 2.2 Ga); (2) antecryst ages ca. 3-15 million years older than SMB emplacement; (3) autocryst delta.sup.18O values between +7.3per thousand and +9.1per thousand (V-SMOW); (4) similar isotopes, REE signatures, and derived fO.sub.2 values among antecrysts and autocrysts; and (5) epsilon.sub.Hf values from the 371.8 + or - 0.8 Ma Davis Lake Pluton (DLP) autocrysts that are higher (+1.74 to +4.38) than the rest of the SMB (-2.99 to +1.68). Collectively these data suggest a protracted magmatic evolution for the SMB with melt generation and assembly from ~390 to 370 Ma via melting of a metasomatized mantle source followed by contamination, first from the structurally underlying Avalonian terrane and later by metasedimentary wall rocks of the Meguma terrane. The most southwesterly part of the SMB (i.e., DLP) represents a petrogenetically distinct magmatic phase that underwent less overall contamination than the rest of the SMB.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This volume assesses the nexus of gender and transboundary water governance, containing empirical case studies, discourse analyses, practitioners’ accounts, and theoretical reflections. Transboundary ...water governance exists at the intersection of two highly masculinised fields: diplomacy and water resources management. In both fields, positions are mainly held by men, and core ideas, norms, and guiding principles that are presented as neutral, are both shaped by men and based on male experiences. This book sheds light on the often hidden gender dynamics of water conflict and cooperation at the transboundary level and on the implicit assumptions that guide research and policies. The individual chapters of the book, based on case studies from around the world, reveal the gendered nature of water diplomacy, take stock of the number of women involved in organisations that govern shared waters, and analyse programmes that have been set up to promote women in water diplomacy and the obstacles that they face. They explore and contest leading narratives and knowledge that have been shaped mainly by privileged men, and assess how the participation of women concretely impacts the practices, routines, and processes of water negotiations. This volume will be of great interest to students and scholars of water governance, water diplomacy, gender, international relations and environmental politics. It will also be of interest to professionals and policymakers involved in supporting gender mainstreaming in water cooperation.
Stephen Gaukroger presents the first English translation of a landmark work in the understanding of the mind, Charles Bonnet's Analytical Essay on the Faculties of the Soul (1760), the first to offer ...a physiological approach to the sensations and operations of the mind.
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