A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters, and nitroalkanes in ...the presence of 10mol% NiCl2·6H2O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies.
Various aromatic aldehydes on reaction with 2-mercaptoethanol provided an unanticipated product, bis(2-hydroxyethyl)dithioacetals (3) as the major product along with the expected product ...1,3-oxathiolanes (4) in the presence of 0.05equiv amount of nickel(II) chloride hexahydrate (NiCl2·6H2O) under solvent-free conditions. Products 3c and 3e exhibit an interesting hydrogen-bonded infinite supra-molecular helical structure.
