Pomen personaliziranega načina zdravljenja se iz leta v leto povečuje, saj je zavedanje, da ljudje nismo popolnoma enaki in da vsak organizem potrebuje sebi lastno terapijo, vedno večje. Poznavanje ...genetike in njenega vpliva na izvor in potek nekaterih bolezni pomen personaliziranega zdravljenja še povečuje. Zato se trenutne raziskave v farmacevtski stroki vedno bolj nagibajo k razvoju in optimizaciji zdravil, ki bi omogočala tak način zdravljenja. V ta namen je dandanes vedno več raziskovalcev, usmerjenih v razvoj nanosa zdravilnih učinkovin (ZU) na podlage z metodo 2D tiskanja, ki zaradi svoje priročnosti, možnosti široke uporabe in enostavnega prilagajanja odmerkov iz dneva v dan pridobiva na vrednosti. Princip tiskanja poteka na enak način kot tiskanje besedilnih dokumentov, le da črnila zamenjamo z disperzijo ZU, medtem ko namesto listov papirja uporabimo različne biološko kompatibilne podlage, ki skupaj z natisnjeno zdravilno učinkovino služijo kot per oralna farmacevtska oblika. Pri tiskanju ZU lahko uporabimo različne vrste tiskalnikov, pri čemer pa vsak izmed njih za uspešno tiskanje zahteva izpolnitev določenih specifikacijskih zahtev. Prednosti, ki jih nanos ZU z metodo 2D tiskanja prinaša, so poleg hitre izdelave personalizirane farmacevtske oblike (FO) z natančnim odmerjanjem tudi hkratno tiskanje in s tem združevanje več ZU hkrati v eno samo FO. Kljub vsemu omenjenemu pa na tem področju še vedno obstaja veliko izzivov, s katerimi se bo potrebno spopasti, preden bo tak način izdelave in odmerjanja zdravil dosegel trg in bil na voljo pacientom.
Cohesive soils are found all over the world and can cause significant harm to infrastructure and structures. Many innovative ways to improve the strength of cohesive soils are being explored to ...decrease the negative qualities and make them appropriate for construction applications. The availability of novel materials, in addition to traditional procedures, has boosted the area of soil reinforcement. In the realm of soil stabilisation, the inclusion of nanomaterials is one of the newest creative ideas. In geotechnical engineering, nanotechnology could be viewed as dual methods: the composition of the soil can be found at the nanoscale, and soil modification can be accomplished at the atomic and molecular levels. The goal of this research is to see if it is possible to stabilise cohesive soil using two distinct nanomaterials and to look at the changes in geotechnical parameters. Nanocrystalline magnesium oxide and nano zinc oxide is included in the soil with (0.25, 0.5, 0.75 and 1) w/% and trials were executed to evaluate the optimal percent and strength properties of the mixtures.
Kljub načelnemu približevanju upravljanja z vodami ter prostorskega načrtovanja v Vodni direktivi (2000) poteka izdelava načrtov upravljanja voda brez upoštevanja širših razvojnih dejavnikov v ...prostoru. V prispevku predlagamo celovitejši oziroma geografski pristop k izdelavi strokovnih podlag kot izhodišče za prostorsko načrtovanje v porečjih, in sicer s povezavo DPSIR modela in strokovnih analiz pri prostorskem načrtovanju. Tako smo povezali okoljski vidik načrtovanja razvoja porečij s širšim razvojnim vidikom. Predlagani pristop smo preverili in ovrednotili na primeru porečja reke Kokre v Sloveniji.
Cherry cultivation has a long tradition in Bosnia and Herzegovina mainly due to favorable climatic conditions for cherry growing in this region. However, current cherry production is insufficient ...because of prevailing old cultivars and rootstocks. Modern intensive production of sweet cherry (Prunus avium L.) requires planting of high quality cultivars on dwarfing rootstocks planted in high density orchards. Cherry rootstock breeding programs worldwide require data on tolerance and performance of their rootstocks in different climatic conditions. Therefore, the influence of two cherry rootstocks ('Gisela 5 and 'Santa Lucia 64') on phenological events (blooming), growth and pomological properties of two cherry cultivars ('Stella' and 'Burlat') planted in modern orchard (managed according to standard commercial practice for integrated fruit production), near Sarajevo was evaluated. The trees grafted on 'Gisela 5' rootstocks were planted in 2004 and on 'Santa Lucia 64' in 2005. All tress were trained in a spindle system and the analyzed parameters were monitored in 2010. Rootstocks greatly influenced blooming time, growth and fruit characteristics of both investigated cultivars. The weaker rootstock was 'Gisela 5', which stimulated earlier blooming and caused statistically significant better fruit characteristics (fruit size, % flesh of fruit as well as total soluble solids content in fruit). The results of the analysis showed that both cherry cultivars reached better fruit quality on 'Gisela 5'. 'Stella' had better fruit quality than 'Burlat'. 'Santa Lucia 64' proved a better rootstock for 'Burlat' than for 'Stella'.
Gojenje češenj v Bosni in Hercegovini ima dolgo tradicijo. Glavni razlog so ugodne klimatske razmere za gojenje češenj. Vendar pa je trenutna pridelava češenj premajhna zaradi starih sort in njihovih podlag. Sodobna intenzivna pridelava češenj (Prunus avium L.) zahteva sajenje visokokakovostnih sort na šibkih podlagah v nasadih z gostim sajenjem. Programi vzgoje novih češnjevih podlag po svetu potrebujejo podatke o odpornosti in obnašanju podlag v različnih klimatskih razmerah. Ugotavljali smo vpliv dveh češnjevih podlag ('Gisela 5' in 'Santa Lucia 64') na fenološke lastnosti (cvetenje), rast in pomološke lastnosti dveh češnjevih sort ('Stella' in 'Burlat'), ki sta bili posajeni v sodobnem nasadu blizu Sarajeva, oskrbovanem po načelih integrirane pridelave. Drevesa na podlagi 'Gisela 5' so bila posajena leta 2004 in na podlagi 'Santa Lucia 64' leta 2005. Drevesa smo opazovali v letu 2010, vzgojena so bila v gojitveni obliki vretenast grm. Podlagi sta značilno vplivali na cvetenje, rast in na značilnosti plodov pri obeh obravnavanih sortah. Šibkejša podlaga je bila 'Gisela 5', kjer je bilo cvetenje zgodnejše in plodovi so imeli boljše značilnosti (velikost ploda, delež mesa kakor tudi vsebnost suhe snovi v plodu). Analiza je pokazala, da sta obe češnjevi sorti razvili bolj kakovostne plodove na podlagi 'Gisela 5'. Sorta 'Stella' je imela kakovostnejše plodove kot sorta 'Burlat'. Za sorto 'Burlat' je podlaga 'Santa Lucia 64' bolj primerna kot za sorto 'Stella'.
Članek analizira potrebne informacijske podlage za posamično tržno vrednotenje nepremičnin. Republika Slovenija na področju tovrstnih informacijskih podlag nima tradicije. V zadnjih letih je ...vzpostavila oziroma posodobila evidence in registre za namen množičnega vrednotenja nepremičnin. Podatki, zbrani za namene množičnega vrednotenja nepremičnin, niso primerni za oblikovanje ustreznih informacijskih podlag za posamično vrednotenje nepremičnin. Ustrezne informacijske podlage bi pripomogle k večji objektivnosti, nepristranskosti in neodvisnosti pri poročanju o tržni vrednosti nepremičnine. Analizirani so pojmi »objektivnost«, »nepristranskost« in »neodvisnost« ter njihova povezanost z informacijskimi podlagami. Prikazani so najpogostejši viri, ki jih cenilci uporabljajo pri svojem delu, ter potrebne informacijske podlage pri posameznih metodah ocenjevanja tržne vrednosti nepremičnin. Prikazana sta metodološki pristop k oblikovanju ustreznih informacijskih podlag v Republiki Sloveniji in konkreten primer oblikovanja sistema povprečnih stroškov gradnje za tipične objekte kot podlaga za ocenjevanje tržne vrednosti nepremičnine po metodi stroškov. This article analyses the information required for a single real estate valuation. The Republic of Slovenia has no tradition for this type of information. Only recently, the records and registers required for the mass real estate valuation were set up or updated. The existing data collected for the mass real estate valuation were inadequate for gathering the information required for the single real estate valuation. More adequate information would contribute to greater objectivity, neutrality and independence of reporting on the market value of a particular real estate. The terms of “objectivity”, “neutrality” and “independence” are analysed as well as their links to adequate information. The most frequent sources used by valuers in their work and the information required for the particular methods of assessing the market value of real estate are presented. The article shows the methodological approach to gathering adequate information in the Republic of Slovenia and presents a concrete example of creating a system of mean construction costs for typical buildings as a basis for assessing the market value of a single real estate item by the cost method.
Si: Članek analizira potrebne informacijske podlage za posamično tržno vrednotenje nepremičnin. Republika Slovenija na področju tovrstnih informacijskih podlag nima tradicije. V zadnjih letih je ...vzpostavila oziroma posodobila evidence in registre za namen množičnega vrednotenja nepremičnin. Podatki, zbrani za namene množičnega vrednotenja nepremičnin, niso primerni za oblikovanje ustreznih informacijskih podlag za posamično vrednotenje nepremičnin. Ustrezne informacijske podlage bi pripomogle k večji objektivnosti, nepristranskosti in neodvisnosti pri poročanju o tržni vrednosti nepremičnine. Analizirani so pojmi »objektivnost«, »nepristranskost« in »neodvisnost« ter njihova povezanost z informacijskimi podlagami. Prikazani so najpogostejši viri, ki jih cenilci uporabljajo pri svojem delu, ter potrebne informacijske podlage pri posameznih metodah ocenjevanja tržne vrednosti nepremičnin. Prikazana sta metodološki pristop k oblikovanju ustreznih informacijskih podlag v Republiki Sloveniji in konkreten primer oblikovanja sistema povprečnih stroškov gradnje za tipične objekte kot podlaga za ocenjevanje tržne vrednosti nepremičnine po metodi stroškov. EN: This article analyses the information required for a single real estate valuation. The Republic of Slovenia has no tradition for this type of information. Only recently, the records and registers required for the mass real estate valuation were set up or updated. The existing data collected for the mass real estate valuation were inadequate for gathering the information required for the single real estate valuation. More adequate information would contribute to greater objectivity, neutrality and independence of reporting on the market value of a particular real estate. The terms of “objectivity”, “neutrality” and “independence” are analysed as well as their links to adequate information. The most frequent sources used by valuers in their work and the information required for the particular methods of assessing the market value of real estate are presented. The article shows the methodological approach to gathering adequate information in the Republic of Slovenia and presents a concrete example of creating a system of mean construction costs for typical buildings as a basis for assessing the market value of a single real estate item by the cost method.
In 2005 the Slovenian Ministry of the Environment and Spatial Planning commenced the activities related to the changing of spatial planning legislation. The working group for spatial planning and ...land management, which is organised as a section of the Association of Surveyors of Slovenia, joined the activities. The working group proposed a guidance for legislation changes and its own comments on the new legislative proposals. Most of the attention was given to the use of spatial data in the process of preparation of spatial planning documents, to the presentation of spatial data together with land cadastre data, to geographic information systems, planning information and to the role of geodesy in the process of preparation and implementation of spatial planning documents.
A system of geodetic data enables administration, management and spatial planning on several levels. For European purposes two datasets, EGM and ERM, have been established, and Slovenia regularly ...contributes data for its own territory. For the strategic state level, the National General Map at 1: 250,000 has been made in 2005. Regional and inter-regional level is covered by the National Topographic Map at 1: 50,000, completed this year for the entire Slovenia. At the local level, the National Topographic Map at 1: 5000 in the vector form has been established. By now, 40 % of the Slovenian territory, mostly of urban areas, has been covered. The geodetic branch provides many other topographic and real estate data for local spatial planning, thus the contribution of geodesists in terms of knowledge in data preparation and cartographic representations is valuable. Detailed Plans are based on Geodetic Plans, which have become, after the recent adoption of regulations, an important part of geodetic service. In field measurements surveyors are supported by the national network of GPS reference stations called SIGNAL. Unfortunately, all spatial data in Slovenia are still inaccurate due to the deformations in the existing national coordinate system; a solution will be provided with the introduction of the European Terrestrial and Vertical Reference Systems.
The purpose of the investigation was to determine the use of water in grafted vines (Vitis vinifera L.) in dependence on the vine (Vitis sp.) rootstocks. The local vine variety 'Rebula' was grafted ...on three different rootstocks (Vitis sp.): (1) on the 'Rebula' (Vitis vinifera L.) vine itself, (2) on the rootstock 196/17 Castel' (Vitis vinifera 'Mourvedre' x Vitis rupestris '1202 Couderc') x Vitis riparia 'Gloire' and (3) on the rootstock 'Börner' (Vitis riparia x Vitis cinerea). Daily transpiration was calculated as a difference in the pot mass between the day of measurement and the previous day. Daily differences in the use of water were compared with leaf area and meteorological data (temperature, duration of sun light). Stem water potential (SWP) and, at the end of the trial, leaf area and mass of individual parts of plant (roots, shoot) were determined using destructive method. The dynamics of water used per leaf area unit showed the trend of reduction and the response to the changing meteorological conditions. No statistically significant differences in SWP, leaf area and water used were noticed between rootstocks, however, they existed in the final mass of shoot and roots.
Namen raziskave je bil določiti porabo vode pri enoletnih cepljenkah vinske trte (Vitis vinifera L.) v odvisnosti od podlage vinske trte (Vitis sp.). Lokalno vinsko sorto 'Rebula' smo cepili na tri različne podlage: (1) na samo sebe, 'Rebula' (Vitis vinifera L.), (2) podlago '196/17 Castel' (Vitis vinifera 'Mourvedre' x Vitis rupestris '1202 Couderc') x Vitis riparia 'Gloire' in (3) podlago 'Börner' (Vitis riparia x Vitis cinerea). Dnevna transpiracija je bila izračunana kot razlika v masi lonca z rastlino, med dnevom merjenja in predhodnim dnevom. Dnevne razlike v porabi vode smo primerjali z listno povr_ino in meteorolo_kimi podatki (temperatura, sončno obsevanje). Določili smo vodni potencial stebla (SWP), na koncu poskusa pa, z destruktivno metodo, listno povr_ino in maso posameznih delov rastlin (korenine, poganjek). Dinamika porabe vode na enoto listne povr_ine je pokazala odziv na spremenljive meteorolo_ke razmere in trend zni_evanja. Med podlagami nismo opazili statistično značilnih razlik v vodnem potencialu stebla, listni povr_ini in porabi vode, statistično značilne razlike med podlagami so obstajale le v končni masi poganjka in korenin.
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