Artykuł jest poświęcony konceptualizacji zmysłów przez Jerzego Pilcha ujętych w ramy interpretacyjne każdego z nich. Dzięki badaniu można dostrzec, jak przedstawia się hierarchia postrzeżeń autora ...oraz które zakresy w nich dominują. Materiał pochodzi z dwóch wczesnych powieści Jerzego Pilcha Spisu cudzołożnic (1993), Innych rozkoszy (1995) oraz ostatnich Zuza albo czas oddalenia (2015) i Portret młodej wenecjanki (2017). Na tej podstawie uzyskuje się obraz przekrojowy wyłaniający się z całości przeprowadzonej próby oraz możliwe jest wychwycenie różnic pomiędzy starszą i nowszą częścią dorobku artysty.
The most popular story in all of India and a classic of world literature is summarised in 728 verses in the great epic Mahabharata. Intended for independent study or classroom use for students of ...various levels who have had a basic introduction to Sanskrit, this fully annotated edition of the Ramopakhyana supplies all the information required for complete comprehension. It contains the Devanagari text, Roman transliteration, sandhi analysis, Sanskrit prose equivalents to the verses, syntactic and cultural notes, and the English translation, and word-by-word grammatical analysis.
Throughout Indian history, many authors and performers have produced, and many patrons have supported, diverse tellings of the story of the exiled prince Rama, who rescues his abducted wife by ...battling the demon king who has imprisoned her. The contributors to this volume focus on these "many" Ramayanas. While most scholars continue to rely on Valmiki's Sanskrit Ramayana as the authoritative version of the tale, the contributors to this volume do not. Their essays demonstrate the multivocal nature of the Ramayana by highlighting its variations according to historical period, political context, regional literary tradition, religious affiliation, intended audience, and genre. Socially marginal groups in Indian society--Telugu women, for example, or Untouchables from Madhya Pradesh--have recast the Rama story to reflect their own views of the world, while in other hands the epic has become the basis for teachings about spiritual liberation or the demand for political separatism. Historians of religion, scholars of South Asia, folklorists, cultural anthropologists--all will find here refreshing perspectives on this tale. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1991. Throughout Indian history, many authors and performers have produced, and many patrons have supported, diverse tellings of the story of the exiled prince Rama, who rescues his abducted wife by battling the demon king who has imprisoned her. The contributo.
Bile represses
serovar Typhimurium (
. Typhimurium) intestinal cell invasion, but it remains unclear which bile components and mechanisms are implicated. Previous studies reported that bile inhibits ...the RamR binding to the
promoter, resulting in
increased transcription, and that
overexpression is associated to decreased expression of type III secretion system 1 (TTSS-1) invasion genes and to impaired intestinal cell invasiveness in
. Typhimurium. In this study, we assessed the possible involvement of the
multidrug efflux regulatory locus and individual bile salts in the bile-mediated repression of
. Typhimurium invasion, using Caco-2 intestinal epithelial cells and
. Typhimurium strain ATCC 14028s. Our results indicate that (i) major primary bile salts, chenodeoxycholate and its conjugated-derivative salts, cholate, and deoxycholate, activate
transcription in a RamR-dependent manner, and (ii) it results in repression of
, encoding the master activator of TTSS-1 genes, and as a consequence in the repression of cellular invasiveness. On the other hand, crude ox bile extract and cholate were also shown to repress the transcription of
independently of RamR, and to inhibit cell invasion independently of
. Altogether, these data suggest that bile-mediated repression of
. Typhimurium invasion occurs through pleiotropic effects involving partly
, as well as other unknown regulatory pathways. Bile components other than the bile salts used in this study might also participate in this phenomenon.
Rama literacko-wydawnicza: stan badań i definicje. Historiografia cystersów z Santa Maria de Alcobaça i jej rama literacko-wydawnicza. Rama literacko-wydawnicza: co mówi nam o relacjach z ...władzą? Wnioski końcowe i food for thought.
The incidence of multidrug-resistant bacteria is increasing globally, with efflux pumps being a fundamental platform limiting drug access and synergizing with other mechanisms of resistance. ...Increased expression of efflux pumps is a key feature of most cells that are resistant to multiple antibiotics. Whilst expression of efflux genes can confer benefits, production of complex efflux systems is energetically costly and the expression of efflux is highly regulated, with cells balancing benefits against costs. This study used TraDIS-
, a genome-wide transposon mutagenesis technology, to identify genes in
and
Typhimurium involved in drug efflux and its regulation. We exposed mutant libraries to the canonical efflux substrate acriflavine in the presence and absence of the efflux inhibitor phenylalanine-arginine β-naphthylamide. Comparisons between conditions identified efflux-specific and drug-specific responses. Known efflux-associated genes were easily identified, including
,
,
,
and
, confirming the specificity of the response. Further genes encoding cell envelope maintenance enzymes and products involved with stringent response activation, DNA housekeeping, respiration and glutathione biosynthesis were also identified as affecting efflux activity in both species. This demonstrates the deep relationship between efflux regulation and other cellular regulatory networks. We identified a conserved set of pathways crucial for efflux activity in these experimental conditions, which expands the list of genes known to impact on efflux efficacy. Responses in both species were similar and we propose that these common results represent a core set of genes likely to be relevant to efflux control across the Enterobacteriaceae.
Los pacientes con un episodio sincopal inexplicable único (ESU) y bloqueo completo de rama del haz de His (BcR) con frecuencia se tratan de manera más conservadora que aquellos con episodios ...recurrentes (ESR). El objetivo fue analizar si existen diferencias entre pacientes con ESU o ESR y BcR en cuanto al riesgo arrítmico, el rendimiento diagnóstico de las pruebas y los resultados clínicos.
Estudio de cohorte de pacientes consecutivos con seguimiento medio de 3 años. Fueron estudiados mediante un protocolo escalonado basado en un estudio electrofisiológico y seguimiento con un monitor cardiaco implantable (MCI).
De los 503 pacientes incluidos en el estudio, 238 (47,3%) referían un ESU. El riesgo de síncope arrítmico fue similar en ambos grupos (58,8% ESU frente a 57,0% ESR; p=0,68), también tras ajustar por variables de confusión (HR=1,06; IC95%, 0,81-1,38; p=0,674). No se encontraron diferencias significativas en cuanto a los resultados del estudio electrofisiológico y la rentabilidad diagnóstica del monitor cardiaco implantable. Un total de 141 (59,2%) pacientes con ESU y 154 (58,1%) con ESR requirieron el implante de un dispositivo cardiaco (p=0,797). Tras el tratamiento adecuado, 35 (7%) pacientes presentaron recurrencia del síncope. La tasa de recurrencia y la mortalidad también fueron similares.
Los pacientes con BcR y síncope tienen un alto riesgo de tener una etiología arrítmica, aunque solo hayan presentado un episodio aislado. Los pacientes con ESU y ESR tienen un riesgo arrítmico similar y presentan un pronóstico similar, por lo que no existe una justificación clínica para no tratarlos de la misma manera.
Patients with a single syncopal episode (SSE) and complete bundle branch block (cBBB) are frequently managed more conservatively than patients with recurrent episodes (RSE). The objective of this study was to analyze if there are differences between patients with single or recurrent unexplained syncope and cBBB in arrhythmic risk, the diagnostic yield of tests, and clinical outcomes.
Cohort study of consecutive patients with unexplained syncope and cBBB with a median follow-up time of 3 years. The patients were evaluated via a stepwise workup protocol based on electrophysiological study (EPS) and long-term follow-up with an implantable cardiac monitor.
Of the 503 patients included in the study, 238 (47.3%) had had only 1 syncopal episode. The risk of an arrhythmic syncope was similar in both groups (58.8% in SSE vs 57.0% in RSE; P=.68), also after adjustment for possible confounding variables (HR, 1.06; 95%CI, 0.81-1.38; P=.674). No significant differences between the groups were found in the EPS results and implantable cardiac monitor diagnostic yield. A total of 141 (59.2%) patients with SSE and 154 (58.1%) patients with RSE required cardiac device implantation (P=.797). After appropriate treatment, 35 (7%) patients had recurrence of syncope. The recurrence rate and mortality were also similar in both groups.
Patients with cBBB and unexplained syncope are at high risk of an arrhythmic etiology, even after the first syncopal episode. Patients with SSE and RSE have a similar arrhythmic risk and similar outcomes, and therefore there is no clinical justification for not managing them in the same manner.
Full English text available from:www.revespcardiol.org/en
Wongprom J, Maneeanakekul S, Tara A, Chandaeng W, Duangnamon D, Rueangket A, Wechakit D, Wanthongchai P, Maknual C. 2023. Vegetation structure and carbon stock of restored mangrove on abandoned ...shrimp pond in the International Mangrove Botanical Garden Rama IX, Thailand. Biodiversitas 24: 5821-5830. The conversion of mangrove forest into shrimp aquaculture has severely impacted biodiversity and increased carbon emissions. Restoration program is thus urgently needed for such mangrove forests. In this study, we investigated the vegetation structure and composition, and biomass and carbon stock of restored mangrove on abandoned shrimp pond. Observation plots at restoration sites with age of 3-year-old (MF3) and 14-year-old (MF14) were established in the International Mangrove Botanical Garden Rama IX, Chanthaburi Province, Thailand and at abandoned shrimp pond (ASP) and protected mangrove forest (PMF) as reference sites. The diameters and heights of mangrove species were measured and identified in order to determine the vegetation structure, composition, biomass, and carbon stock. Soil samples from four soil depths, i.e. 0-15, 15-30, 30-50, and 50-100 cm, were collected to quantify the soil carbon stock. The results showed the good growth of Rhizophora stand planted at the restored sites with high vegetation biomass and carbon stock. This species also promoted species diversity, suggesting that Rhizophora spp. are suitable species for the restoration of abandoned shrimp pond. The vegetation biomass and carbon stock of MF14 (230.99 t ha-1 and 102.54 t C ha-1, respectively) was higher than that of PMF (133.84 t ha-1 and 64.94 t C ha-1, respectively). Higher vegetation and soil carbon stocks of the restored mangrove forest was positively influenced by the Rhizophora stand. However, the ecosystem carbon pool of PMF was higher (366.38 t C ha-1). This result indicates that the conservation of mangrove forest is significant to maintain the forest diversity, ecosystem function, and reducing carbon emissions, while mangrove forest restoration is essential to improve the vegetation structure and increase the soil and vegetation carbon stocks.
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