Though the signaling events involved in radiation induced bystander effects (RIBE) have been investigated both
and
, the spatial function of these communications, especially the related signaling ...pathways, is not fully elucidated. In the current study, significant increases of DNA damage were clearly observed in
germline upon irradiation to both intra-system of posterior pharynx and inter-system of vulva, in which more severe damage, even to F1 generation worms, was shown for vulva irradiation. Spatial function assay indicated the DDR key components of
were indispensable in germ cells for both sites irradiation, while those components in somatic cells were either not (
) or partially (
) required to promote apoptosis. Moreover, production of reactive oxygen species (ROS) indicated by the superoxide dismutase expression and the unfolded protein response of the mitochondria was found systemically involved in the initiation of these processes for both two site irradiation. These results will give a better understanding of the RIBE mechanisms
, and invaluable to assess the clinical relevance to radiotherapy.
We prove that finite lamplighter groups \{\mathbb{Z}_2\wr \mathbb{Z}_n\}_{n\ge 2} with a standard set of generators embed with uniformly bounded distortions into any non-superreflexive Banach space ...and therefore form a set of test spaces for superreflexivity. Our proof is inspired by the well-known identification of Cayley graphs of infinite lamplighter groups with the horocyclic product of trees. We cover \mathbb{Z}_2\wr \mathbb{Z}_n by three sets with a structure similar to a horocyclic product of trees, which enables us to construct well-controlled embeddings.
Recently security plays a crucial part throughout the communication framework. In the most recent decade, organizations have endeavored to move from a paper-concentrated environment to a sans paper ...environment where data security is one of the essential issues, and any weakness in this respect can have crushing impacts. Security implies the assurance of the data from any unauthorized access or manipulation through spying or scientific or probabilistic calculations and different strategies. For the security of information, researchers are doing more work on ID-based Cryptography (IDC). However, it has two limitations: one suffers from an inherent key escrow problem, and the second is how to revoke the misbehavior/compromised user. Tseng and Tsai have proposed a novel Revocable ID-Based Encryption (RIBE). Yet, they have not considered the key escrow problem. This paper proposed an approach in which secure key issuance is done only for non-revocable ID. This will reduce the key escrow problem as multiple entities rather than one Private Key Generator (PKG) issue the key. It will reduce the possibility of compromised PKG as the private key is cooperatively issued by PKG and multiple Key Privacy Authorities (KPAs).
•Determinants of nitrofurantoin (NIT) resistance in Escherichia coli clinical isolates were studied.•Plasmid-encoded efflux pump OqxAB was not involved in NIT resistance in E. coli clinical ...isolates.•Genetic alterations in nitroreductases NfsA and NfsB were the main mediators of nitrofurantoin resistance.•RibE of most NIT-resistant isolates was unaffected, indicating a minor or no role for this protein in resistance.
The worldwide emergence of multidrug-resistant uropathogens has resulted in the revival of old antibiotics such as nitrofurantoin (NIT) for the treatment of uncomplicated urinary tract infections (UTIs). This study aimed to identify determinants of NIT resistance and to investigate the genetic diversity of NIT-resistant (NIT-R) Escherichia coli isolates.
Six NIT-R and three NIT-susceptible clinical E. coli isolates from patients with UTI were studied. The susceptibility of the isolates to various classes of antibiotics was evaluated by disk diffusion. The presence of plasmid-encoded efflux pump genes (oqxA and oqxB) was investigated by PCR. Nucleotide sequences of the nfsA, nfsB and ribE genes were determined. The genetic relatedness of the NIT-R isolates was evaluated by multilocus sequence typing (MLST).
All six NIT-R isolates were characterised with high-level NIT resistance (MIC ≥ 512 mg/L) and they belonged to five distinct STs including ST131 (n = 2), ST73, ST405, ST10 and ST354 (n = 1 each). Amikacin, carbapenems, minocycline, tigecycline and fosfomycin were the most active agents against the studied uropathogens. The oqxA and oqxB genes were not detected in any isolate. All NIT-R isolates harboured inactivating genetic alterations in nfsA and nfsB NfsA H11Y, S33N, S38Y, W212R substitutions, Δg638 (frameshift), Δa64-g73 (frameshift) and NfsB F84S, P45S, W94Stop, E197Stop substitutions, ΔnfsB locus. The ribE gene of most isolates was unaffected, except for one isolate co-harbouring a deleterious RibE G85C substitution and NfsA/B alterations.
NIT resistance in the studied E. coli isolates was mainly mediated by nfsA and nfsB alterations.
Fish are the most commonly cultivated vertebrates in the world. They respond to stress like other vertebrates, and they can feel pain, fear and suffering. These facts are the basis for considering ...their welfare. The question of formal protection of fish welfare is becoming more relevant with the significant development of aquaculture in the last few decades. However, fish welfare protection is encountering difficulties. Like many terrestrial farm animals, farmed fish are often subjected to poor living conditions and cruelty. Harvesting, transport, and stunning and killing are the most significant welfare issues. This review describes some of the most important procedures that compromise animal welfare during fish farming and the negative effects these procedures have on the fish. It also gives a brief overview of the situation in Serbia in terms of research into fish welfare, public attitudes on this issue, and the state of legislation. Data presented in this paper indicate the need for more effective protection of fish welfare in the legal and executive aspects.
Det er nu 50 år siden, man midt på sommeren i 1973 gjorde et af landets mest spændenderunefund i Ribe. Efterfølgende kunne interesserede i flere danske dagblade læse noglesmå artikler, som i ...forskellige versioner bar overskriften ”Danmarks ældste brev er fundet!”De bragte også fotografier af den mærkelige genstand, der var dukket op af undergrunden:et stykke af en menneskelig hjerneskal tæt beskrevet med runer. Desuden havde nogle afaviserne en ret indgående udredning af sagen. Den daværende leder af Ribes AntikvariskeSamling, mag. art. Mogens Bencard, berettede om begivenhedens detaljer, og Nationalmuseetsruneekspert, dr. phil. Erik Moltke, diskuterede indskriftens indhold. Kort sagtbetragtede forskerne, helt fra den såkaldte "Ribe Hjerneskal" dukkede op af jorden, fundetsom noget af en sensation.
Stanje ribarstva u neposrednim poslijeratnim godinama u Istri za vrijeme Vojne uprave Jugoslavenske armije od 1945. do 1947. godine nije se često javljalo kao istraživačka tema. Problem svakako leži ...i u maloj količini arhivskoga gradiva koje se dotiče ove teme. S obzirom, dakle, na ograničen prostorni i vremenski okvir teme ovoga rada u uvodnim se poglavljima pruža kratak osvrt na stanje ribarstva i industrije prerade ribe u Istri u razdoblju od pokretanja prerađivačke ribarske industrije (kraj 19. st.) pa do kraja Drugoga svjetskog rata, a potom detaljnije na ponovno pokretanje rada te industrije neposredno po svršetku rata. U radu se ukazuje na neke od brojnih izazova s kojima se poslijeratna vlast suočila u obnovi i organizaciji samoga ribolova te u industriji prerade ribe. Za pokretanje ribarstva nužan je preduvjet bila uspostava suradnje sa svim uključenim sudionicima toga procesa. Taj zadatak nije se moglo postići isključivo strogim i tvrdim nametanjem nove doktrine , već postupnim upoznavanjem stanovništva s promjenama koje su nastupale i koje će utjecati na sve društvene procese. »Popularizacija« budućega privrednog napretka zemlje obuhvatila je i ribarstvo te se i u toj industrijskoj grani od svih uključenih, počevši od samih ribara pa do zaposlenih u prerađivačkim pogonima, očekivao doprinos u izgradnji bolje ekonomske budućnosti. Vlasti su svojim prvim potezima prvenstveno išle prema uspostavi reda i nadzora nad novim područjem te prema obuhvatnom uvidu u stanje gospodarskih resursa Istre. Komunističke su vlasti poduzimale napore da tehnološki unaprijede i olakšaju uvjete rada i ribolova i prerade. Uz pružanje pomoći ribarima jednako su tako kontinuirano ulagani napori u stvaranje boljih uvjeta i nesmetana rada u tvornicama za preradu. Poseban je izazov predstavljao nedostatak cjelogodišnjih zaliha potrebnih za kontinuiranu proizvodnju, potom pomanjkanje radne snage, pogotovo stručnoga kadra, te problem plasmana gotovih proizvoda. Ovo su bile stalne prepreke za koje su poslijeratne vlasti morale tražiti i stalno iznalaziti odgovarajuća rješenja. Gradivo fonda HR-DAPA-79 Oblasni narodni odbor za Istru (1945-1947) sadrži dokumente koji svjedoče o procesu obnove gospodarske djelatnosti u Istri, a samim time omogućuju detaljniju rekonstrukciju toga procesa.
The state of fisheries in the immediate post-war years in Istria during the Military Administration of the Yugoslav Army between 1945 and 1947 did not often arise as a research topic. The problem certainly lies also in the small amount of archival material addressing this topic. Given, therefore, the limited spatial and temporal framework of the topic of this paper, the introductory chapters provide a brief overview of the state of fishing and the fish processing industry in Istria in the period from the start of the fishing industry (end of the 19th century) until the end of the Second World War, and then, in more detail, of the resumption of the activities of that industry immediately after the end of the war. The paper points out some of the numerous challenges that the post-war government faced in the reconstruction and organization of fishing and the fish processing industry. The establishment of cooperation with all stakeholders in the process was a necessary prerequisite for the relaunching of fishing. This task could not be achieved solely by a strict and harsh imposition of a new doctrine, but by gradually familiarizing the population with the changes which were being introduced and which would affect all social processes. The "popularization" of the country's future economic progress also included fishing, and everyone involved in this industrial branch, starting from the fishermen and ending with the employees of processing plants, was expected to contribute to building a better economic future. The authorities' first moves were primarily aimed at establishing order and supervision over the new area, and at providing a comprehensive insight into the state of economic resources in Istria. The communist authorities undertook efforts to technologically improve and facilitate the conditions of work of both fishing and processing. In addition to providing assistance to fishermen, efforts were also continuously made to create better conditions and smooth functioning in the processing plants. A special challenge was the lack of year-round supplies needed for continuous production, the lack of manpower, especially qualified personnel, and the problem of placing finished products. These were constant obstacles which the post-war authorities had to tackle and constantly find appropriate solutions for. The fonds HR-DAPA-79 Regional People's Committee for Istria (1945-1947) contains documents that bear witness to the process of rehabilitation of economic activity in Istria, thus enabling a more detailed reconstruction of that process.
La situazione relativa all'attività di pesca negli anni dell'immediato dopoguerra in Istria, durante l'Amministrazione militare dell'Armata jugoslava, dal 1945 al 1947, non appariva spesso tra i temi di ricerca. Il problema sta ovviamente anche nella piccola quantità di materiale archivistico che affronta questo argomento. Quindi, prendendo in considerazione il limitato quadro spaziale e temporale del tema di questo lavoro, nei capitoli introduttivi viene riportato un breve cenno sulla situazione relativa all'attività di pesca e all'industria di lavorazione del pesce in Istria nel periodo che va dall'avvio dell'industria di lavorazione del pesce ( fine del XIX secolo) alla fine della Seconda guerra mondiale, e successivamente, in modo più dettagliato, sul riavviamento dell'attività industriale subito dopo la fine della guerra. Il testo denota alcune delle numerose sfide affrontate dalle autorità del dopoguerra relative al ripristino e all' organizzazione della pesca e dell'industria di lavorazione del pesce. Per l'avvio della pesca un presupposto importante è stato quello di instaurare la collaborazione con tutti gli attori coinvolti nel processo. Questo compito non si poteva realizzare esclusivamente imponendo in modo rigoroso e duro una nuova dottrina ma facendo conoscere gradualmente agli abitanti i cambiamenti verificati che avrebbero influenzato tutti i processi sociali. La „popolarizzazione“ della futura crescita economica del Paese ha interessato anche il settore della pesca e, di conseguenza, da tutti gli attori coinvolti in questo settore dell'industria, dai pescatori ai lavoratori negli impianti di lavorazione, ci si aspettava un contributo nella creazione di un futuro economico migliore. Le prime mosse delle autorità erano finalizzate a stabilire l'ordine e la vigilanza del nuovo territorio e a ottenere una visione completa dello stato delle risorse economiche dell'Istria. Le autorità comuniste si sono impegnate a migliorare tecnologicamente e ad agevolare le condizioni di lavoro sia della pesca che della lavorazione del pesce. Oltre ad aiutare i pescatori ci si impegnava costantemente a creare condizioni migliori garantendo un buon funzionamento degli impianti di trasformazione. Una sfida particolare era rappresentata dalla mancanza di scorte necessarie per la produzione ininterrotta su base annua, la carenza di manodopera, soprattutto di personale qualificato, e il problema di commercializzazione dei prodotti finiti. Questi erano gli ostacoli costanti per cui le autorità del dopoguerra hanno dovuto cercare e trovare soluzioni adeguate. Il materiale del fondo HR-DAPA-79 Comitato popolare regionale per l'Istria (1945-1947) contiene documenti che testimoniano il processo di ripristino dell' attività economica in Istria, e, di conseguenza, consentono una ricostruzione più dettagliata di tale processo.
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