A Dozen Years, A Dozen Roses Lapeña, José Florencio F.
Philippine journal of otolaryngology head & neck surgery,
11/2018, Letnik:
33, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Twelve years have passed since my first editorial for the Philippine Journal of Otolaryngology Head and Neck Surgery, on the occasion of the silver anniversary of our journal and the golden ...anniversary of the Philippine Society of Otolaryngology – Head and Neck Surgery (PSO-HNS).1 Special editorials have similarly marked our thirtieth (pearl)2 and thirty-fifth (coral or jade)3 journal anniversaries, punctuating editorials on a variety of themes in between. Whether they were a commentary on issues and events in the PSO-HNS or Philippine Society, or on matters pertaining to medical research and writing, publication and peer review, I have often wondered whether my words fell on deaf ears. But write, must I-- despite my writer’s doubt.
What then, do a dozen years symbolize? As a baby boomer, I am all too familiar with what “cheaper by the dozen” meant in daily life, outwardly displayed in the matching attire my siblings and I wore on special occasions -- such as Yuletide when we would sing the carol “twelve days of Christmas.”4 We read the comedy “Twelfth Night”5 in school, although I admittedly enjoyed “The Dirty Dozen”6 more than Shakespeare. College ROTC introduced me to the “Daily Dozen” and the grueling Navy count- 1,2,3, ONE! One, two, three, TWO! (One, two, three, four! I love the Marine Corps!) And that is as far as my list of memorable dozens goes, covering five dozen years of life.
Of these, one fifth or 20% of my life has been devoted to our journal. From that perspective, I cannot help but wonder whether, or how it mattered. After 12 years, the day-to-day routine has hardly changed; neither have the periodic problems that precede the birth of each issue. I still find it difficult to solicit and follow-up reviews, and I still burn the midnight oil on weekends and holidays, patiently guiding authors in revising their manuscripts. Nevertheless, our journal has come a long way from where it was when we started (although it has not reached as far and as quickly as I would have wanted it to). Much depends on our authors and the caliber of their contributions, and our reviewers and the quality and timeliness of their reviews. However, despite our efforts to conduct education and training sessions on Medical Writing and Peer Review, the new batch of submissions and reviews each year evinces the need to repeat these regularly. In this regard, the increasing response-ability of our associate editors and continuing support of our society are needed to ensure our progress.
This year, we welcome Dr. Eris Llanes as our new Managing Editor as we thank and congratulate Dr. Tony Chua (who retains his position as Associate Editor) for serving in that role for the past 12 years. We have finally migrated from our previous platform to the Public Knowledge Platform - Open Journal Systems (PKP-OJS) available from https://pjohns.pso-hns.org/index.php/pjohns/index. The PSO-HNS has become a member of the Publishers International Linking Association (PILA), which manages and maintains, deposits and retrieves, Metadata and Digital Identifiers inclusive of associated software and know-how. This will enable us to register Digital Object Identifiers (DOIs) for all our content using the Crossref® system (https://www.crossref.org/about/), making our “research outputs easy to find, cite, link, and assess.”7 We are also subscribing to the Crossref® Similarity Check plagiarism detection software service powered by iThenticate® (https://www.crossref.org/services/similarity-check/)7 and are exploring ways and means of converting all our articles to eXtensible Markup Language (XML) format. These steps reflect our continuing efforts to comply with the requirements for indexing in the Directory of Open Access Journals (DOAJ)8 and our re-application for indexing in Scopus®.9 These steps would not have been possible without the full support of the PSO-HNS Board of Trustees under the leadership of our President, Dr. Aggie Remulla, for which we are truly grateful.
Indeed, the past 12 years may represent a complete cycle (such as 12 hours on a clock, or months in a year, or 12 signs of the zodiac), the first steps in the rebirth of our journal. Although they may not count among the “memorable dozens” of my life, each of these years may be likened to a rose (with its attendant thorns) – a bouquet of a dozen roses that I offer to all of you.
“for there’s no rose without a thorn,
no night without the morn,
no gain without some meaningful loss …”10
The purpose of the study is to mix some medicinal plant powders with the food diet and to compare them with the Amberolium antibiotic and to study their effect as dietary aids in improving the ...hematological , serological, and productive characteristics of the broiler chickens (Rose 308).The four types of medicinal plants were added to the Rose308 broiler Rosemary ,peel of pomegranate, pine and willow plants, and treatment of amberolium was added to water at a concentration of 0.5 g / L. our research includes studies the following : complete blood pictures, biochemical blood parameters ,and all the results oversoften to SSD statistic programs.The results of the study showed that the cumulative performance characteristics of the period (1-42 days) showed significant differences (P< 0.05) For the treatment of control compared with other treatments. It was found that the best treatment in improving the performance characteristics when mixed with the diet and calculating the length of time of breeding period and the body's resistance to diseases and the percentage of losses is the treatment to which the pomegranate powder was added compared with the production characteristics of the other treatments and compared with the control , And the treatment was reduced from the loss rate. The efficiency of the pomegranate peel powder to the type of active ingredient may have been widely used in commercial medical treatments, and the blood parameters ratios of this treatment were closely correlated with the control ratios. As it had an active role in increasing the amount of( Hb , RBC and Platelate) and lower the levels of ESR compared with control and the rest of the other transactions, either serological factors which include: (Total serum protein, albumins, uric acid, creatinine)& (Lipid TC, TG, HDL).It was also found that giving some natural extracts of plants has led to a significant stability of the serological factors. (lipid TC, TG, HDL), and some natural extracts of plants have resulted in significant stability in the results, The final results of our study found that peel of pomegranate powder was the best treatment in terms of improvement of the performance traits and the indicators of the hemolytic , serological and ionic characteristics, while the lowest of the above indicators was in the powder of rosemary leave.
Rose bengal has been used in the diagnosis of ophthalmic disorders and liver function, and has been studied for the treatment of solid tumor cancers. To date, the antibacterial activity of rose ...bengal has been sporadically reported; however, these data have been generated with a commercial grade of rose bengal, which contains major uncontrolled impurities generated by the manufacturing process (80-95% dye content). A high-purity form of rose bengal formulation (HP-RBf, >99.5% dye content) kills a battery of Gram-positive bacteria, including drug-resistant strains at low concentrations (0.01-3.13 μg/mL) under fluorescent, LED, and natural light in a few minutes. Significantly, HP-RBf effectively eradicates Gram-positive bacterial biofilms. The frequency that Gram-positive bacteria spontaneously developed resistance to HP-RB is extremely low (less than 1 × 10
). Toxicity data obtained through our research programs indicate that HP-RB is feasible as an anti-infective drug for the treatment of skin and soft tissue infections (SSTIs) involving multidrug-resistant (MDR) microbial invasion of the skin, and for eradicating biofilms. This article summarizes the antibacterial activity of pharmaceutical-grade rose bengal, HP-RB, against Gram-positive bacteria, its cytotoxicity against skin cells under illumination conditions, and mechanistic insights into rose bengal's bactericidal activity under dark conditions.
Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy ...(PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using these techniques. The ability to deliver oxygen to the vicinity of the tumour increases its local partial pressure improving the possibility of ROS generation in PDT/SDT. In this manuscript, we investigate the use of oxygen-loaded, lipid-stabilised microbubbles (MBs), decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo. We directly compare the effectiveness of the oxygen-loaded MBs with sulphur hexafluoride (SF6)-loaded MBs and reveal a significant improvement in therapeutic efficacy. The combination of oxygen-carrying, ultrasound-responsive MBs, with an ultrasound-responsive therapeutic sensitiser, offers the possibility of delivering and activating the MB-sensitiser conjugate at the tumour site in a non-invasive manner, providing enhanced sonodynamic activation at that site.
We report a preliminary study of phototransferred thermoluminescence (PTTL) induced by 470 nm light source in rose quartz. The glow curve corresponding to 1 Gy consists of five peaks at 76, 115, 180, ...290 and 423 °C labelled I through V in that order. In the PTTL experiments employing blue light. PTTL was regenerated at peak I following preheating to remove peak I only and at peaks I and II otherwise. The dependence of the PTTL intensity on duration of illumination is analyzed in terms of a system of one acceptor and two donors in both cases. The mechanisms for the PTTL phenomena in the rose quartz are comprehensively discussed in this paper.
•Phototransferred thermoluminescence (PTTL) of rose quartz induced by 470 nm is reported.•The sample presented five TL glow peaks at 76 °C (I), 115 °C (II), 180 °C (III), 290 °C (IV), and 423 °C (V).•Only peaks I and II are reproduced by PTTL using blue light.•The pulse annealing showed peaks I and II likely present one acceptor and two donors in the PTTL signal.•Dependence on illumination time results shows a good fit when using the equation based on one acceptor and two donors (peak I and II), demonstrating a good correlation between pulse annealing prediction and the model.
Rosa damascena Mill. is one of the rosa species that is broadly used for commercial products such as rose concrete and rose absolute. First, the effect of two organic solvents of hexane and ethyl ...acetate and three alcohols of methanol, ethanol, and 2-propanol were studied on the yield and quality of the rose concrete and rose absolute from air-dried petals of Rosa damascena Mill. Then, a predictive thermodynamic model based on the UNIFAC activity coefficient was employed to predict the composition of rose absolute obtained from the rose concrete. The extraction of rose concrete from dried rose petals was performed at 30 °C by hexane or ethyl acetate, and then the produced rose concrete was combined with an alcohol and the mixture was placed at −18 °C for 48 h to produce rose absolute. Based on the results, the maximum yield of rose absolute was achieved if the extractions were performed with ethyl acetate to extract rose concrete, and ethanol to extract rose absolute. The extracts were analyzed using a GC-MS method to determine the effect of the solvents on the quality of the rose absolute. The most critical constituents detected in the extracts were high-value fragrant components of phenyl ethyl alcohol, citronellol, geraniol, nerol, and farnesol. The results showed that using the pair of hexane and methanol led to achieving a rose absolute with the highest odor value (16,038) but a low extraction yield. Using ethyl acetate and ethanol, the maximum yield of rose absolute was achieved. Finally, the thermodynamic model showed a good agreement in predicting the rose absolute production from the rose concrete with the alcohols.
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•The highest quality rose absolute was obtained by the pair of hexane and methanol.•The maximum yield of the fragrants was obtained by ethyl acetate and ethanol.•Rose absolute production from rose concrete was predicted by a thermodynamic model.•The model showed good accuracy in predicting the rose absolute composition.
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