Spiders of the World Platnick, Norman I; Jocque, Rudy; Hormiga, Gustavo ...
06/2020, Letnik:
2
eBook
A stunningly illustrated natural history of spiders Spiders are among the most versatile creatures on the planet, inhabiting six of the seven continents and thriving in environments ranging from ...deserts and rain forests to Arctic tundra and cities. Spiders of the World is a captivating look at these wondrously adaptable and endlessly intriguing arachnids, written by six of the world's leading experts on spiders. This stunningly illustrated natural history features a wealth of spectacular color photos and covers a breathtaking array of spider species from around the globe, describing their behaviors, characteristics, and remarkable evolutionary adaptations. An incisive and engaging introduction provides an invaluable overview of the world's spiders, and is followed by in-depth profiles spanning more than 100 spider families and presented taxonomically. Each profile is organized phylogenetically and includes beautiful photography to illustrate various species within the family. There are also distribution maps, tables of essential facts, and commentaries highlighting diverse aspects of spider biology, making Spiders of the World an indispensable volume for anyone who wants to learn more about these marvelous creatures. Provides a richly illustrated look at spiders of all shapes and sizes from around the world Features hundreds of color photos and diagrams Spans more than 100 spider families and covers an array of different species Explores spider behavior, attributes, biology, and evolution Includes distribution maps, tables of essential facts, informative commentaries, and more Engages and educates readers about the unique natural history of spiders
Spiders are among the most diverse groups of terrestrial invertebrates, yet they are among the least studied and understood. This first comprehensive guide to all 68 spider families in North America ...beautifully illustrates 469 of the most commonly encountered species. Group keys enable identification by web type and other observable details, and species descriptions include identification tips, typical habitat, geographic distribution, and behavioral notes. A concise illustrated introduction to spider biology and anatomy explains spider relationships. This book is a critical resource for curious naturalists who want to understand this ubiquitous and ecologically critical component of our biosphere.
Spiders have been incriminated as causes of human suffering for centuries, but few species worldwide cause medically significant envenomation. Widow spiders (Latrodectus spp.) occur worldwide and ...cause latrodectism, which is characterized by pain (local and generalized) associated with nonspecific systemic effects, diaphoresis, and less commonly other autonomic and neurological effects. Recluse spiders (Loxosceles spp.) are distributed mostly through the tropical and subtropical Western Hemisphere and can cause severe skin lesions and rarely systemic effects; most bites are unremarkable. Highly dangerous spiders in South America (armed spiders) and Australia (funnel-web spiders) cause rare but severe envenomation requiring medical intervention and sometimes antivenom. Most other spiders involved in verified bites cause minor, transient effects. Many spiders blamed for causing medical mischief have been elevated to medical significance via circumstantial evidence, poor reporting, and repetitive citation in the literature; several species have been shown to be harmless with more stringent scientific evidence involving verified bites in humans.
The Loxosceles genus spiders (the brown spiders) are encountered in all the continents, and the clinical manifestations following spider bites include skin necrosis with gravitational lesion ...spreading and occasional systemic manifestations, such as intravascular hemolysis, thrombocytopenia and acute renal failure. Brown spider venoms are complex mixtures of toxins especially enriched in three molecular families: the phospholipases D, astacin-like metalloproteases and Inhibitor Cystine Knot (ICK) peptides. Other toxins with low level of expression also present in the venom include the serine proteases, serine protease inhibitors, hyaluronidases, allergen factors and translationally controlled tumor protein (TCTP). The mechanisms by which the Loxosceles venoms act and exert their noxious effects are not fully understood. Except for the brown spider venom phospholipase D, which causes dermonecrosis, hemolysis, thrombocytopenia and renal failure, the pathological activities of the other venom toxins remain unclear. The objective of the present review is to provide insights into the brown spider venoms and loxoscelism based on recent results. These insights include the biology of brown spiders, the clinical features of loxoscelism and the diagnosis and therapy of brown spider bites. Regarding the brown spider venom, this review includes a description of the novel toxins revealed by molecular biology and proteomics techniques, the data regarding three-dimensional toxin structures, and the mechanism of action of these molecules. Finally, the biotechnological applications of the venom components, especially for those toxins reported as recombinant molecules, and the challenges for future study are discussed.
•Data from the last 13 years of brown spider venom and loxoscelism.•Overview of the biology of brown spiders and the loxoscelism.•Molecular biology and proteomic analysis are shown.•Molecular mechanisms of the main toxins are discussed.•The biotechnological use of toxins and future directions are approached.
We present the case of a 32-year-old male patient hospitalized during the COVID-19 pandemic because of a Brown spider bite on his lower lip. The Brown spider accident occurred in southern Brazil; at ...hospital admission, the patient presented on his lip: edema, pustules, necrotic regions, and ulcerations. The patient complained of lower back pain, fever and dyspnea. Laboratory tests showed monocytosis, leukocytosis, neutrophilia, increased D-dimer levels, C-reactive protein, glutamate-pyruvate transaminase, delta bilirubin, creatine phosphokinase, procalcitonin, and fibrinogen. The patient was hospitalized and a multi-professional team carried out the treatment. The medical team diagnosed loxoscelism with moderate changes. The dentist treated the oral cavity. The patient began to develop nausea, vomiting, and desaturation episodes during hospitalization. A computed tomography of the chest was performed, which showed signs of viral infection. The RT-PCR test for COVID-19 was positive. The systemic conditions worsened (renal dysfunction, systemic inflammatory response, pulmonary complications). This condition may have resulted from the association of the two diseases (loxoscelism and COVID-19), leading to the patient's death. This case illustrates the difficulties and risks in treating patients with venomous animal accidents during the pandemic, and the importance of a multi-professional team in treating such cases.
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•Describes a local and systemic reaction to a Brown spider bite on the lower lip.•The combined systemic effect of Brown spider venom and SARS-CoV-2 infection.•Special attention in treating patients after Brown spider bites.•Loxoscelism -a condition that increases and exacerbates inflammatory response.
Loxosceles rufescens is a circum-Mediterranean spider species, potentially harmful to humans. Its native area covers the Mediterranean Basin and Near East. Easily spread with transported goods, it is ...meanwhile an alien and invasive species to nearly all other continents and many islands. This species occurs in semi-arid steppe-like habitats, typically under stones and in cavities, which enables it to settle inside buildings when invading the synanthropic environment. This review analyses the literature of L. rufescens bites to humans (38 publications) of which only 11 publications refer to 12 verified spider bites (11% of the reported bites). Two published allegedly deadly spider bites (Thailand 2014 and Italy 2016) involve non-verified spider bites and are thus not reliable. The symptoms and therapy of these 11 verified bites are described: only five cases showed moderate systemic effects, nine cases developed necrosis, four cases needed surgical debridement, all cases healed without complications within a few weeks. In conclusion, L. rufescens is a spider species globally spread by human activity, it rarely bites humans and the bites are less harmful than often described. There is no known fatal issue.
•Loxosceles rufescens is a Mediterranean spider, globally spread and invasive in the human environment.•We analyse 38 publications of L. rufescens bite reports to humans where only 10% were verified bites.•Two published cases of alleged deathly bites (Thailand 2014, Italy 2016) refer to non-verified bites and are not reliable.•All 11 cases of verified bites healed without complications within a few weeks.•L. rufescens rarely bites humans, the bites are less harmful than described and there is no known fatal issue.
Brown spiders and loxoscelism da Silva, Paulo Henrique; da Silveira, Rafael Bertoni; Helena Appel, Márcia ...
Toxicon (Oxford),
12/2004, Letnik:
44, Številka:
7
Journal Article
Recenzirano
Accidents caused by brown spiders (
Loxosceles genus) are classically associated with dermonecrotic lesions and systemic manifestations including intravascular haemolysis, disseminated intravascular ...coagulation and acute renal failure. Systemic reactions occur in a minority of cases, but may be severe in some patients and occasionally fatal. The mechanisms by which
Loxosceles venom exerts these noxious effects are currently under investigation. The venom contains several toxins, some of which have been well-characterised biochemically and biologically. The purpose of the present review is to describe some insights into loxoscelism obtained over the last ten years. The biology and epidemiology of the brown spider, the histopathology of envenomation and the immunogenicity of
Loxosceles venom are reviewed, as are the clinical features, diagnosis and therapy of brown spider bites. The identification and characterisation of some toxins and the mechanism of induction of local and systemic lesions caused by brown spider venom are also discussed. Finally, the biotechnological application of some venom toxins are covered.
Spiders of the genus
, popularly known as Brown spiders, are considered a serious public health issue, especially in regions of hot or temperate climates, such as parts of North and South America. ...Although the venoms of these arachnids are complex in molecular composition, often containing proteins with distinct biochemical characteristics, the literature has primarily described a family of toxins, the Phospholipases-D (PLDs), which are highly conserved in all
species. PLDs trigger most of the major clinical symptoms of loxoscelism i.e., dermonecrosis, thrombocytopenia, hemolysis, and acute renal failure. The key role played by PLDs in the symptomatology of loxoscelism was first described 40 years ago, when researches purified a hemolytic toxin that cleaved sphingomyelin and generated choline, and was referred to as a Sphingomyelinase-D, which was subsequently changed to Phospholipase-D when it was demonstrated that the enzyme also cleaved other cellular phospholipids. In this review, we present the information gleaned over the last 40 years about PLDs from
venoms especially with regard to the production and characterization of recombinant isoforms. The history of obtaining these toxins is discussed, as well as their molecular organization and mechanisms of interaction with their substrates. We will address cellular biology aspects of these toxins and how they can be used in the development of drugs to address inflammatory processes and loxoscelism. Present and future aspects of loxoscelism diagnosis will be discussed, as well as their biotechnological applications and actions expected for the future in this field.
Spiders have been evolving complex and diverse repertoires of peptides in their venoms with vast pharmacological activities for more than 300 million years. Spiders use their venoms for prey capture ...and defense, hence they contain peptides that target both prey (mainly arthropods) and predators (other arthropods or vertebrates). This includes peptides that potently and selectively modulate a range of targets such as ion channels, receptors and signaling pathways involved in physiological processes. The contribution of these targets in particular disease pathophysiologies makes spider venoms a valuable source of peptides with potential therapeutic use. In addition, peptides with insecticidal activities, used for prey capture, can be exploited for the development of novel bioinsecticides for agricultural use. Although we have already reviewed potential applications of spider venom peptides as therapeutics (in 2010) and as bioinsecticides (in 2012), a considerable number of research articles on both topics have been published since, warranting an updated review. Here we explore the most recent research on the use of spider venom peptides for both medical and agricultural applications.
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•Spider venoms contain a huge diversity of potent and target-selective peptides with a correspondingly vast array of pharmacological activities.•Their potential medical applications have focused on the treatment of diseases such as stroke, cancer, pain and erectile dysfunction.•They also have great potential for application in agriculture as environmentally benign bioinsecticides.
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