The Cost of Being Landlocked Arvis, Jean-Francois; Marteau, Jean-Francois; Raballand, Gael
2010, 07-07-2010, 20100101, 20100701
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In the last two decades new emphasis has been given to the economic impact of geography, especially on the cost of being landlocked. From a development perspective, understanding the cost of being ...landlocked and its economic impact is critical, since one country of four in the world is landlocked (almost one out of three in Sub-Saharan Africa). Attempts to address the cost of being landlocked have mainly focused on regional and multilateral conventions aiming at ensuring freedom of transit, and on the development of regional transport infrastructure. The success of these measures has been limited, and many massive investments in infrastructure seem to have had a disappointing impact on landlocked economies. Although there may still be an infrastructure gap, this book, based on extensive data collection in several regions of the world, argues that logistics and trade services efficiency can be more important for landlocked countries than investing massively in infrastructure. Logistics have become increasingly complex and critical for firms' competitiveness, and a weakness in this field can badly hurt firms based in landlocked countries. This book proposes a revised approach to tackling the cost of being landlocked and a new analytical framework which uses a microeconomic approach to assess the trade and macroeconomic impacts of logistics. It takes into account recent findings on the importance of logistics chain uncertainty and inventory control in firms' performance. It argues that: (i) exporters and importers in landlocked developing countries face high logistics costs, which are highly detrimental to their competitiveness in world markets, (ii) high logistics costs depend on low logistics reliability and predictability, and (iii) low logistics reliability and predictability result mostly from rent-seeking and governance issues (prone to proliferate in low volume environments).
Trade in Zimbabwe Newfarmer, Richard; Pierola, Martha Denisse
2015., 2015, 5-26-2015, 2015-05-22, 20150501
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In Zimbabwe trade has been a driver of economic growth, rising incomes, and progressive empowerment of Zimbabweans through rising standards of living and the promise of better jobs. Since 1980, ...through good years and bad years, increases in exports have been positively associated with increases in national income. Zimbabwe's location and resource base, together with a low- cost but relatively well educated labor force, have endowed it with a naturally high trade ratio built on a diversified base that facilitates using trade as an engine of growth. While trade volumes have rebounded smartly from the deep recession of 2007-2008, these do not offset other worrisome longer- term trends: 1) export growth during the last decade has been lackluster and failed to drive high growth; 2) agricultural exports, other than tobacco, have lost their once dominant role in the region, and are no longer a source of diversification; 3) manufacturing has withered in a continuing secular decline; and 4) Zimbabwe's export basket has become less diversified and more dependent on a narrow range of mineral and, to a lesser extent, agricultural products. In short, exports have become less diversified, less-technologically sophisticated, and less labor-intensive, and ever more dependent on a few large mining activities to provide foreign exchange and employment. This report traces the roots of this poor performance to several policy issues: poor predictability of macroeconomic policy and economic governance has created an unfavorable climate for private investment and trade; a tariff structure that dampens export profitability; industrial policies (indigenization policy in particular) that undermine investor confidence and inhibits private investment; and finally, competition-limiting policies toward services that limit connectivity of Zimbabweans and raise trade costs. The good news arising from the study is that the remedies for these policy shortcomings lie in Zimbabwean hands. If the government were to adopt reforms that reconfigure economy-wide incentives and trade and industrial policies, it could promote sustained growth, economic diversification and empowerment of poor people.
Road freight transport is indispensable
to international economic cooperation and foreign trade.
Across all continents, it is commonly used for short and
medium distances and in long distance haulage ...when
minimizing time is important. In all instances governments
play a critical role in ensuring the competitive advantage
of private sector operators. Countries often have many
opportunities to minimize the physical or administrative
barriers that increase costs, take measures to enhance the
attractiveness and competitiveness of road transport, or
generally nurture the integral role of international road
freight transport in the global trade logistics industry.
Road freight transport is critical to domestic and
international trade. It is the dominant mode of transport
for overland movement of trade traffic, carrying more than
80 percent of traffic in most regions. Generally, nearly all
trade traffic is carried by road at some point. Therefore,
the cost and quality of road transport services is of
critical importance to trade competitiveness of countries
and regions within countries. In fact, road transport is
fundamental to modern international division of labor and
supply-chain management.
The objective of the study is to
examine, identify, and quantify the factors behind
Africa's high prices for road transport. Such prices
are a major obstacle to economic growth in the region, as
...shown in several studies. For example, Amjadi and Yeats
(1995) concluded that transport costs in Africa were a
higher trade barrier than were import tariffs and trade
restrictions. Other analyses by the World Bank (2007a)
demonstrated that Africa's transport prices were high
compared to the value of the goods transported and that
transport predictability and reliability were low by
international standards. This study's findings should
help policy makers take actions that will reduce transport
costs to domestic and international trade.
Long-lived proteins (LLPs) have recently emerged as vital components of intracellular structures whose function is coupled to long-term stability. Mitochondria are multifaceted organelles, and their ...function hinges on efficient proteome renewal and replacement. Here, using metabolic stable isotope labeling of mice combined with mass spectrometry (MS)-based proteomic analysis, we demonstrate remarkable longevity for a subset of the mitochondrial proteome. We discovered that mitochondrial LLPs (mt-LLPs) can persist for months in tissues harboring long-lived cells, such as brain and heart. Our analysis revealed enrichment of mt-LLPs within the inner mitochondrial membrane, specifically in the cristae subcompartment, and demonstrates that the mitochondrial proteome is not turned over in bulk. Pioneering cross-linking experiments revealed that mt-LLPs are spatially restricted and copreserved within protein OXPHOS complexes, with limited subunit exchange throughout their lifetimes. This study provides an explanation for the exceptional mitochondrial protein lifetimes and supports the concept that LLPs provide key structural stability to multiple large and dynamic intracellular structures.
Mitochondrial energy conversion requires an intricate architecture of the inner mitochondrial membrane
. Here we show that a supercomplex containing all four respiratory chain components contributes ...to membrane curvature induction in ciliates. We report cryo-electron microscopy and cryo-tomography structures of the supercomplex that comprises 150 different proteins and 311 bound lipids, forming a stable 5.8-MDa assembly. Owing to subunit acquisition and extension, complex I associates with a complex IV dimer, generating a wedge-shaped gap that serves as a binding site for complex II. Together with a tilted complex III dimer association, it results in a curved membrane region. Using molecular dynamics simulations, we demonstrate that the divergent supercomplex actively contributes to the membrane curvature induction and tubulation of cristae. Our findings highlight how the evolution of protein subunits of respiratory complexes has led to the I-II-III
-IV
supercomplex that contributes to the shaping of the bioenergetic membrane, thereby enabling its functional specialization.
Lattice Boltzmann models have a remarkable ability to simulate single- and multi-phase fluids and transport processes within them. A rich variety of behaviors, including higher Reynolds numbers ...flows, phase separation, evaporation, condensation, cavitation, buoyancy, and interactions with surfaces can readily be simulated. This book provides a basic introduction that emphasizes intuition and simplistic conceptualization of processes. It avoids the more difficult mathematics that underlies LB models. The model is viewed from a particle perspective where collisions, streaming, and particle-particle/particle-surface interactions constitute the entire conceptual framework. Beginners and those with more interest in model application than detailed mathematical foundations will find this a powerful 'quick start' guide. Example simulations, exercises, and computer codes are included. Working code is provided on the Internet.
The primary reference for the modeling of hydrodynamics and water quality in rivers, lake, estuaries, coastal waters, and wetlands This comprehensive text perfectly illustrates the principles, basic ...processes, mathematical descriptions, case studies, and practical applications associated with surface waters. It focuses on solving practical problems in rivers, lakes, estuaries, coastal waters, and wetlands. Most of the theories and technical approaches presented within have been implemented in mathematical models and applied to solve practical problems. Throughout the book, case studies are presented to demonstrate how the basic theories and technical approaches are implemented into models, and how these models are applied to solve practical environmental/water resources problems. This new edition of Hydrodynamics and Water Quality: Modeling Rivers, Lakes, and Estuaries has been updated with more than 40% new information. It features several new chapters, including one devoted to shallow water processes in wetlands as well as another focused on extreme value theory and environmental risk analysis. It is also supplemented with a new website that provides files needed for sample applications, such as source codes, executable codes, input files, output files, model manuals, reports, technical notes, and utility programs. This new edition of the book: * Includes more than 120 new/updated figures and 450 references * Covers state-of-the-art hydrodynamics, sediment transport, toxics fate and transport, and water quality in surface waters * Provides essential and updated information on mathematical models * Focuses on how to solve practical problems in surface waters—presenting basic theories and technical approaches so that mathematical models can be understood and applied to simulate processes in surface waters Hailed as "a great addition to any university library" by the Journal of the American Water Resources Association (July 2009), Hydrodynamics and Water Quality, Second Edition is an essential reference for practicing engineers, scientists, and water resource managers worldwide.
A ubiquitous feature of neurotransmitter transporters is the presence of short C-terminal PDZ binding motifs acting as important trafficking elements. Depending on their very C-terminal sequences, ...PDZ binding motifs are usually divided into at least three groups; however this classification has recently been questioned. To introduce a 3D aspect into transporter's PDZ motif similarities, we compared their interactions with the natural collection of all 13 PDZ domains of the largest PDZ binding protein MUPP1. The GABA, glycine and serotonin transporters showed unique binding preferences scattered over one or several MUPP1 domains. On the contrary, the dopamine and norepinephrine transporter PDZ motifs did not show any significant affinity to MUPP1 domains. Interestingly, despite their terminal sequence diversity all three GABA transporter PDZ motifs interacted with MUPP1 domain 7. These results indicate that similarities in binding schemes of individual transporter groups might exist. Results also suggest the existence of variable PDZ binding modes, allowing several transporters to interact with identical PDZ domains and potentially share interaction partners in vivo.
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an ...AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery. Depletion or hypomorphic mutation of AIF caused a downregulation of CHCHD4 protein by diminishing its mitochondrial import. CHCHD4 depletion sufficed to induce a respiratory defect that mimicked that observed in AIF-deficient cells. CHCHD4 levels could be restored in AIF-deficient cells by enforcing its AIF-independent mitochondrial localization. This modified CHCHD4 protein reestablished respiratory function in AIF-deficient cells and enabled AIF-deficient embryoid bodies to undergo cavitation, a process of programmed cell death required for embryonic morphogenesis. These findings explain how AIF contributes to the biogenesis of respiratory chain complexes, and they establish an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.
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•AIF interacts with CHCHD4, a regulator of the intermembrane space import machinery•AIF regulates specific respiratory chain complexes by acting upstream of CHCHD4•AIF is indispensable for translation-coupled mitochondrial import of CHCHD4•Restoring CHCHD4 reverses the metabolic and cell death phenotypes of Aif−/y ESCs
Hangen et al. show that the mitochondrial protein AIF regulates the biogenesis of respiratory chain complexes by interacting with, and by controlling the mitochondrial import of the mammalian homolog of yeast MIA40, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery.
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