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  • Določanje protiteles IgA proti tkivni transglutaminazi poveča ugotavljanje pogostnosti celiakije pri ožjih družinskih članih bolnikov s celiakijo = Determination of IgA antibodies to tissue transglutaminase increase the prevalence of celiac disease at immediate family members of celiac patients
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    Background. It is well known that celiac disease is common with the relatives of the patients with celiac disease. At the healthy immediate family members of the patients with celiac disease silent, ... latent or potential form of celiacdisease can be established. Patients and methods. 149 immediate family members of 50 children and one mother celiac disease were examined at the Pediatric clinic from 1997 till 1999. Anamnesis, clinical examination, determination of stool pH, presence of reducing substances and digestion were carried out. Blood samples were taken for complete blood cell count and for screening tests for celiac disease (IgA AGA, IgG AGA, IgA EMA) and at 140 relatives also IgAtTG. Results. Positive screening tests (IgA and IgG AGA, IgAEMA and IgAtTG) were established at 39 (26.17%) immediate relatives. Endoscopic examination was performed at 32 (21.48%) immediate family members. Silent and latent celiac disease was established at 10 (6.71%) and potential celiac disease at 13 (8.72%) relatives. Silent, latent and potential celiac disease thus established at 23 (15.43%) relatives. At three relatives (at one with the silent and two with the latent celiac disease) of all test only IgA tTG was positive. Conclusions. Early diagnosis and strict gluten-free diet prevents most of the known complications of celiac disease. Because of that itis advised that all four screening tests (IgA and IgG AGA, IgA EMA and IgAtTG) are performed at the immediate family members.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 70, št. 4, april 2001, str. 213-217)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - slovenski
    COBISS.SI-ID - 13341657

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