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  • Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia
    Anticevic, Alan ...
    Bipolar illness is a debilitating neuropsychiatric disorder associated with alterations in the ventral anterior cingulate cortex (vACC), a brain region thought to regulate emotional behavior. ... Although recent data-driven functional connectivity studies provide evidence consistent with this possibility, the role of vACC in bipolar illness and its pattern of whole brain connectivity remain unknown. Furthermore, no study has established whether vACC exhibits differential whole brain connectivity in bipolar patients with and without cooccurring psychosis and whether this pattern resembles that found in schizophrenia. We conducted a human resting- state functional connectivity investigation focused on the vACC seed in 73 remitted bipolar I disorder patients (33 with psychosis history), 56 demographically matched healthy comparison subjects, and 73 demographically matched patients with chronic schizophrenia. Psychosis history within the bipolar disorder group corresponded with significant between-group connectivity alterations along the dorsal medial prefrontal surface when using the vACC seed. Patients with psychosis history showed reduced connectivity (Cohen's d = -0.69), whereas those without psychosis history showed increased vACC coupling (Cohen's d = 0.8) relative to controls. The vACC connectivity observed in chronic schizophrenia patients was not significantly different from that seen in bipolar patients with psychosis history but was significantly reduced compared with that in bipolar patients without psychosis history. These robust findings reveal complex vACC connectivity alterations in bipolar illness, which suggest differences depending on co-occurrence of lifetime psychosis. The similarities in vACC connectivity patterns in schizophrenia and psychotic bipolar disorder patients may suggest the existence of common mechanisms underlying psychotic symptoms in the two disorders.
    Vrsta gradiva - separat ; neleposlovje za odrasle
    Založništvo in izdelava - Oxford : Oxford University Press, 2015
    Jezik - angleški
    COBISS.SI-ID - 55259746

    Povezava(-e):

    http://schizophreniabulletin.oxfordjournals.org/content/41/1/133.full.pdf+html

    Dostop iz prostorov UL in z oddaljenim dostopom za študente in zaposlene UL



Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
FF, Osrednja humanistična knjižnica, Ljubljana OHK - Psihologija
 Sep REPOVŠ G. Ventral anterior 		prosto - na dom, čas izposoje: 7 dni
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