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  • Primerjava učinkovitosti cefpiramida (tamicin) in cefotaksima pri zdravljenju hudih bolnišničnih in izvenbolnišničnih okužb = Treatment of serious hospital and community acquired infection: cefpiramide (tamicin) versus cefotaxime
    Muzlovič, Igor ...
    Backgraund. The activity of cefpiramide is usually compared to activity of cefoperazone against P. aeruginosa. It has about the same activity as cefotaxim and ceftriaxone against gram negative ... bacteria. In prospective randomised clinical trial the activity of cefpiramide (Tamicin/R) was comparedto that of cefotoxim in patients who suffered from serious nosocomial and community acquired infections. Methods. Thirty-one patients with pneumonia, sepsis or urinary tract infection were randomly assigned to one of the two groups. Patients in the first group received intravenous cefpiramide and patients in the second group received intravenous cefotaxim. There was no difference between groups according to demographic characteristics. Results. Cefpiramide was clinically successful in 85.7% and 78.5% of cases showed eradication of causative pathogen. Cefotaxim was clinically successful in 76.4% and eradication rate was 85.7%. The most frequent isolated bacteria in both groups were E. coli, K. pneumoniae and P. aeruginosa. E. cloacae was morefrequently in cefpiramide group and S. aureus in cefotaxim group. There were no differences in the both groups according to colonization, superinfection or side effects. Conclusions. Cefpiramide and cefotaxim were equally effective and safe in patients with serious hospital and community acquired infections. Treatment with these drugs is recommended in infections that are not multiresistant in origin.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Let. 66, št. 3, 1997, str. 123-126)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - slovenski
    COBISS.SI-ID - 7249625

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