E-viri
Recenzirano
-
Quinn, Rachael W., PhD; Hilbert, Stephen L., MD, PhD; Bert, Arthur A., MD; Drake, Bill W., MD; Bustamante, Julie A., RN; Fenton, Jason E., RN; Moriarty, Sara J., BS; Neighbors, Stacy L., RNFA; Lofland, Gary K., MD; Hopkins, Richard A., MD
The Annals of thoracic surgery, 07/2011, Letnik: 92, Številka: 1Journal Article
Background Because of cryopreserved heart valve–mediated immune responses, decellularized allograft valves are an attractive option in children and young adults. The objective of this study was to investigate the performance and morphologic features of decellularized pulmonary valves implanted in the right ventricular outflow tract of juvenile sheep. Methods Right ventricular outflow tract reconstructions in juvenile sheep (160 ± 9 days) using cryopreserved pulmonary allografts (n = 6), porcine aortic root bioprostheses (n = 4), or detergent/enzyme–decellularized pulmonary allografts (n = 8) were performed. Valve performance (echocardiography) and morphologic features (gross, radiographic, and histologic examination) were evaluated 20 weeks after implantation. Results Decellularization reduced DNA in valve cusps by 99.3%. Bioprosthetic valves had the largest peak and mean gradients versus decellularized valves ( p = 0.03; p < 0.001) and cryopreserved valves ( p = 0.01; p = 0.001), which were similar ( p = 0.45; p = 0.40). Regurgitation was minimal and similar for all groups ( p = 0.16). No cusp calcification was observed in any valve type. Arterial wall calcification was present in cryopreserved and bioprosthetic grafts but not in decellularized valves. No autologous recellularization or inflammation occurred in bioprostheses, whereas cellularity progressively decreased in cryopreserved grafts. Autologous recellularization was present in decellularized arterial walls and variably extending into the cusps. Conclusions Cryopreserved and decellularized graft hemodynamic performance was comparable. Autologous recellularization of the decellularized pulmonary arterial wall was consistently observed, with variable cusp recellularization. As demonstrated in this study, decellularized allograft valves have the potential for autologous recellularization.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.