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Kumagai, Shogo; Togashi, Yosuke; Kamada, Takahiro; Sugiyama, Eri; Nishinakamura, Hitomi; Takeuchi, Yoshiko; Vitaly, Kochin; Itahashi, Kota; Maeda, Yuka; Matsui, Shigeyuki; Shibahara, Takuma; Yamashita, Yasuho; Irie, Takuma; Tsuge, Ayaka; Fukuoka, Shota; Kawazoe, Akihito; Udagawa, Hibiki; Kirita, Keisuke; Aokage, Keiju; Ishii, Genichiro; Kuwata, Takeshi; Nakama, Kenta; Kawazu, Masahito; Ueno, Toshihide; Yamazaki, Naoya; Goto, Koichi; Tsuboi, Masahiro; Mano, Hiroyuki; Doi, Toshihiko; Shitara, Kohei; Nishikawa, Hiroyoshi
Nature immunology, 11/2020, Letnik: 21, Številka: 11Journal Article
Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the success of this approach is very variable; therefore, biomarkers predictive of clinical efficacy are urgently required. Here, we show that the frequency of PD-1 CD8 T cells relative to that of PD-1 regulatory T (T ) cells in the tumor microenvironment can predict the clinical efficacy of programmed cell death protein 1 (PD-1) blockade therapies and is superior to other predictors, including PD ligand 1 (PD-L1) expression or tumor mutational burden. PD-1 expression by CD8 T cells and T cells negatively impacts effector and immunosuppressive functions, respectively. PD-1 blockade induces both recovery of dysfunctional PD-1 CD8 T cells and enhanced PD-1 T cell-mediated immunosuppression. A profound reactivation of effector PD-1 CD8 T cells rather than PD-1 T cells by PD-1 blockade is necessary for tumor regression. These findings provide a promising predictive biomarker for PD-1 blockade therapies.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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