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Marek-Trzonkowska, Natalia; Myśliwiec, Małgorzata; Dobyszuk, Anita; Grabowska, Marcelina; Derkowska, Ilona; Juścińska, Jolanta; Owczuk, Radosław; Szadkowska, Agnieszka; Witkowski, Piotr; Młynarski, Wojciech; Jarosz-Chobot, Przemysława; Bossowski, Artur; Siebert, Janusz; Trzonkowski, Piotr
Clinical immunology (Orlando, Fla.) 153, Številka: 1Journal Article
It is hypothesized that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30×10(6)/kg. No severe adverse effects were observed. The treatment did not impair post-immunization antibody responses. Tregs infusion was followed by increase in Tregs number in peripheral blood. Most of the patients responded to the therapy with increase in C-peptide levels (8/12 and 4/6 after the first and the second dose, respectively). Tregs administration resulted also in lower requirement for exogenous insulin (8/12 treated patients versus 2/10 untreated controls in remission) with two children completely insulin independent at one year. Repetitive administration of Tregs is safe and can prolong survival of β-cells in DM1 (registration: ISRCTN06128462).
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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