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Rhee, C. K.; Yoo, K. H.; Lee, J. H.; Park, M. J.; Kim, W. J.; Park, Y. B.; Hwang, Y. I.; Kim, Y. S.; Jung, J. Y.; Moon, J. Y.; Rhee, Y. K.; Park, H. K.; Lim, J. H.; Park, H. Y.; Lee, S. W.; Kim, Y. H.; Lee, S. H.; Yoon, H. K.; Kim, J. W.; Kim, J. S.; Kim, Y. K.; Oh, Y. M.; Lee, S. D.; Kim, H. J.
The international journal of tuberculosis and lung disease, 01/2013, Letnik: 17, Številka: 1Journal Article
SETTING: Multicentre study.OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011.RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1.CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.
