Laryngeal edema is a known complication of endotracheal intubation that may cause airway obstruction upon extubation. The only test available to predict this complication is the cuff leak test (CLT). Given the uncertainty of the CLT's clinical utility, we conducted the COMIC ( uff Leak Test and Airway bstruction in echanically Ventilated U Patients) pilot study to examine the feasibility of undertaking a larger trial. COMIC is a multicentered, parallel-group randomized trial performed in Canada, Saudi Arabia, and Poland. We enrolled mechanically ventilated adults admitted to the intensive care unit who were deemed ready for extubation. Those allocated to the intervention arm had the results of their CLT communicated to the healthcare team, who then decided to proceed with extubation or not. In those randomized to the control arm, the CLT results were not communicated to the healthcare team and patients were extubated, regardless of the CLT result. The primary outcomes focused on feasibility. One hundred patients (56 in the intervention and 44 in the control arm) were enrolled. All feasibility criteria were met, including ) recruitment rate of 7.6 patients/month, ) consent rate of 88.3% (95% confidence interval CI, 82.1-94.5%), and ) protocol adherence of 98% (95% CI, 95-100%). There were two episodes of clinically significant stridor in the intervention group and four patients who required reintubation in each group. The results of the COMIC pilot trial support the feasibility of a larger trial to determine the effect of the CLT on reintubation and clinically important stridor.Clinical trial registered with www.clinicaltrials.gov (NCT03372707).