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Recenzirano
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Kwietniewska, Małgorzata; Cybulska, Regina; Kwietniewski, Piotr; Sekita-Krzak, Joanna; Czerny, Krystyna
Annales Universitatis Mariae Curie-Skłodowska. Sectio D, Medicina, 2002, Letnik: 57, Številka: 2Journal Article
The experiment was carried out on rabbit females of New Zealand breed weighing about 3 kg. The animals from the experimental group received. Cladribine in the dose of 0.1 mg/kg for 7 days. Specimens of retina were collected for ultrastructural examinations. It was revealed that administration of Cladribine in the dose corresponding to the therapeutic dose used in human for the treatment of the hairy cell leukemia causes morphological changes in ultrastructure of retinal ganglion cells which are classified as reversible in cytophysiology. The necessity of periodic, regular ophthalmological examinations during Cladribine treatment was indicated.
