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Buttmann, Mathias; Rieckmann, Peter
Expert review of neurotherapeutics, 20/3/1/, Letnik: 7, Številka: 3Journal Article
In 1993, interferon (IFN)-β 1b for subcutaneous injection became the first US FDA-approved immunomodulatory treatment for multiple sclerosis, a chronic inflammatory disease of the CNS. In this review of IFN-β 1b , we first present a short introduction to multiple sclerosis and currently available therapeutics. We then summarize current knowledge about the biochemical structure of IFN-β 1b , as well as pharmacokinetics and pharmacodynamics, including data on putative mechanisms underlying therapeutic as well as adverse effects. Furthermore, a critical review of ongoing and recently published clinical trials investigating IFN-β 1b in multiple sclerosis will be provided. Main topics are: trials investigating IFN-β 1b after a first clinical event, at higher dosages or in comparison to once-weekly subcutaneous IFN-β 1a injections, 16 years of long-term follow-up, IFN-β 1b in Japanese patients, the role of neutralizing antibodies, biomarkers for the prediction of therapy response, IFN-β 1b and pregnancy, and IFN-β 1b treatment of children with multiple sclerosis. Finally, we discuss how novel drugs, especially monoclonal antibodies and orally administered immunosuppressants, might soon challenge the position of this well-established agent on the multiple sclerosis therapeutics market.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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