Although pathology is the gold standard for confirming the diagnosis of prostate cancer (PCa), several marker for diagnosis may be useful and will helpin doubtful cases to confirm the diagnosis of PCa. Therfore it is important to spread the knowledge of immunomarker, in order to improve the clinicians understanding of stains and their usefulness. Like in other organs, clinicians and pathologists would like not to rely only on pathological criteria such as PSA, Gleason score, tumor size and pT stage, but also on tumor stains, permitting to predict prognosis and patients outcome, especially in patients with intermediate risk. Many markers have been proposed, but none is at the very moment approuved for current use.