E-viri
Recenzirano
Odprti dostop
-
Galsky, Matthew D; Daneshmand, Siamak; Izadmehr, Sudeh; Gonzalez-Kozlova, Edgar; Chan, Kevin G; Lewis, Sara; Achkar, Bassam El; Dorff, Tanya B; Cetnar, Jeremy Paul; Neil, Brock O; D'Souza, Anishka; Mamtani, Ronac; Kyriakopoulos, Christos; Jun, Tomi; Gogerly-Moragoda, Mahalya; Brody, Rachel; Xie, Hui; Nie, Kai; Kelly, Geoffrey; Horowitz, Amir; Kinoshita, Yayoi; Ellis, Ethan; Nose, Yohei; Ioannou, Giorgio; Cabal, Rafael; Del Valle, Diane M; Haines, G Kenneth; Wang, Li; Mouw, Kent W; Samstein, Robert M; Mehrazin, Reza; Bhardwaj, Nina; Yu, Menggang; Zhao, Qianqian; Kim-Schulze, Seunghee; Sebra, Robert; Zhu, Jun; Gnjatic, Sacha; Sfakianos, John; Pal, Sumanta K
Nature medicine, 11/2023, Letnik: 29, Številka: 11Journal Article
Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering. We initiated a phase 2 study in which patients with MIBC received four cycles of gemcitabine, cisplatin, plus nivolumab followed by clinical restaging. Patients achieving a clinical complete response (cCR) could proceed without cystectomy. The co-primary objectives were to assess the cCR rate and the positive predictive value of cCR for a composite outcome: 2-year metastasis-free survival in patients forgoing immediate cystectomy or <ypT1N0 in patients electing immediate cystectomy. Seventy-six patients were enrolled; of these, 33 achieved a cCR (43%, 95% confidence interval (CI): 32%, 55%), and 32 of 33 who achieved a cCR opted to forgo immediate cystectomy. The positive predictive value of cCR was 0.97 (95% CI: 0.91, 1), meeting the co-primary objective. The most common adverse events were fatigue, anemia, neutropenia and nausea. Somatic alterations in pre-specified genes (ATM, RB1, FANCC and ERCC2) or increased tumor mutational burden did not improve the positive predictive value of cCR. Exploratory analyses of peripheral blood mass cytometry and soluble protein analytes demonstrated an association between the baseline and on-treatment immune contexture with clinical outcomes. Stringently defined cCR after gemcitabine, cisplatin, plus nivolumab facilitated bladder sparing and warrants further study. ClinicalTrials.gov identifier: NCT03451331 .
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.