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Ashraf, R.; Vasiljevic, T.; Day, S.L.; Smith, S.C.; Donkor, O.N.
Journal of functional foods, 01/2014, Letnik: 6Journal Article
Immuno-modulatory effects of seventeen lactic acid bacteria (LAB) and probiotic strains were assessed following stimulation with peripheral blood mononuclear cells. Pro- and anti-inflammatory cytokines including interleukin (IL)-2, IL-4, IL-10, IL-12 p70, interferon (IFN)-γ, tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β measured at different time points shows that all strains stimulated significant cytokines in varying concentrations and strain specific manner. Overall, TNF-α, IFN-γ, IL-10 and TGF-β were stimulated at high concentrations where Lactobacillus casei 290 and Streptococcus thermophilus M5 stimulated TNF-α and IFN-γ and Bifidobacterium strains stimulated maximum levels of IL-10 and TGF-β respectively. A significant increase in CD3+CD4+CD25+ and Treg population was observed where S. thermophilus M5 and 1342, B. animalis subsp. lactis BB12 and L. casei 290 showed seven-fold increase in FoxP3 expression. The study suggests that LAB and probiotics strains differ in their immuno-modulatory responses and functions, which necessitates their careful selection and characterization before applications.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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