E-viri
Recenzirano
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Maestrini, E; Rivella, S; Tribioli, C; Purtilo, D; Rocchi, M; Archidiacono, N; Toniolo, D
Genomics (San Diego, Calif.), 12/1990, Letnik: 8, Številka: 4Journal Article
We have isolated and characterized 55 EagI-containing genomic DNA clones from the distal long arm of the human X chromosome. The presence of additional sites for rare-cutter restriction enzymes and the demethylation of the corresponding genomic DNA demonstrate that at least 30 clones correspond to CpG islands of the Xq24-Xqter region. All clones were regionally mapped with a hybrid panel. The majority are in Xq28 and Xq24 (18 and 14 clones, respectively), 15 are in the Xq26-Xq27 interval, and none is in Xq25. This analysis demonstrates a nonuniform distribution of CpG islands that may reflect the distribution of coding regions in this part of the genome.
