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Dawson, V L; Dawson, T M; Filloux, F M; Wamsley, J K
Life sciences (1973), 1988, Letnik: 42, Številka: 20Journal Article
The aziridinium ion of ethylcholine (AF64A) is a neurotoxin that has demonstrated selectivity for cholinergic neurons. Unilateral stereotaxic injection of AF64A into the caudate-putamen of rats, resulted in a decrease in dopamine D-2 receptors as evidenced by a decrease in 3H-sulpiride binding. Dopamine D-1 receptors, labeled with 3H-SCH 23390, were unchanged. The efficacy of the lesion was demonstrated by the reduction of Na+-dependent high affinity choline uptake sites labeled with 3H-hemicholinium-3. These data indicate that a population of D-2 receptors are postsynaptic on cholinergic interneurons within the striatum of rat brain.
