E-viri
Recenzirano
Odprti dostop
-
Jansen, Iris E; Savage, Jeanne E; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina S; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Bjornsson, Sigurbjorn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan; Desikan, Rahul S; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J; Jonsson, Palmi V; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid B; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G; Snaedal, Jon; Stordal, Eystein; Ulstein, Ingun D; Wang, Yunpeng; White, Linda R; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick F; van der Flier, Wiesje M; Dobson, Richard; Davis, Lea K; Stefansson, Hreinn; Stefansson, Kari; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole A; Posthuma, Danielle
Nature genetics, 03/2019, Letnik: 51, Številka: 3Journal Article
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (r = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.