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André, Thierry; Shiu, Kai-Keen; Kim, Tae Won; Jensen, Benny Vittrup; Jensen, Lars Henrik; Punt, Cornelis; Smith, Denis; Garcia-Carbonero, Rocio; Benavides, Manuel; Gibbs, Peter; de la Fouchardiere, Christelle; Rivera, Fernando; Elez, Elena; Bendell, Johanna; Le, Dung T; Yoshino, Takayuki; Van Cutsem, Eric; Yang, Ping; Farooqui, Mohammed Z.H; Marinello, Patricia; Diaz, Luis A
New England journal of medicine/The New England journal of medicine, 12/2020, Letnik: 383, Številka: 23Journal Article
Colorectal cancer is genetically heterogeneous. Tumors in some patients have defects in mismatch DNA repair. These tumors have a high level of mutations that can lead to immune recognition. In a group of patients with microsatellite-unstable tumors, pembrolizumab led to longer progression-free survival and was less toxic than standard chemotherapy.
