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Stalens, Caroline; Motté, Leslie; Béhin, Anthony; Ben Yaou, Rabah; Leturcq, France; Bassez, Guillaume; Laforêt, Pascal; Fontaine, Bertrand; Ederhy, Stéphane; Masingue, Marion; Saadi, Malika; Louis, Sarah Leonard; Berber, Nawal; Stojkovic, Tanya; Duboc, Denis; Wahbi, Karim
Journal of neuromuscular diseases, 01/2021, Letnik: 8, Številka: 4Journal Article
The latest practice guidelines from the American College of Cardiology/American Heart Association recommend the prescription of an ACE-i for patients presenting with non-ischemic cardiomyopathy when left ventricular ejection fraction (LVEF) falls below 40%. To determine if the initiation of treatment with an angiotensin-converting enzyme inhibitor (ACE-i) earlier than recommended by practice guidelines issued by professional societies improves the long-term cardiac outcomes of patients presenting with Becker muscular dystrophy (MD) cardiomyopathy. From a multicenter registry of Becker MD, we selected retrospectively patients presenting between January 1990 and April 2019 with a LVEF ≥40 and ≤49%. We used a propensity score analysis to compare the risk of a) hospitalization for management of heart failure (HF), and b) a decrease in LVEF to <35% in patients who received an ACE-i when LVEF fell below 40% (conventional treatment), versus below 50% (early treatment). From the 183 patients entered in our registry, we identified 85 whose LVEF was between 40 and 49%, 51 of whom received early and 34 received conventional ACE-i treatment. Among patients with early versus conventional treatments, 2 (3.9%) versus 4 (11.8%) were hospitalized for management of HF hazard ratio (HR) 0.151; 95% confidence interval (CI) 0.028 to 0.822; p = 0.029, and 9 (17.6%) versus 10 (29.4%) had a decrease in LVEF below 35% (HR 0.290; 95% CI 0.121 to 0.694; p = 0.005). The long-term cardiac outcome of patients presenting with Becker MD was significantly better when treatment with ACE-i was introduced after a decrease in LVEF below 50%, instead of below 40% as recommended in the current practice guidelines issued by professional societies.
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in: SICRIS
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