To analyze the prognostic factors of transfusion-dependent non-severe aplastic anemia (TD-NSAA) patients treated with cyclosporine A (CsA) and androgen. Clinical data of 77 consecutive TD-NSAA patients treated with CsA and androgen were retrospectively analyzed between 2010 and 2013. We obtained clinical manifestations and baseline parameters of routine blood test from responders, and compared those with non-responders. All data were analyzed by univariate analysis and multivariate analysis. In 77 patients, there were 43 (55.8%) patients achieved hematological response after 6 months'treatment, and 53 (68.8%) patients got response after 12 months. Univariate analysis showed that platelets baseline was the only factor related to hematological response 19 (6-61) ×10(9)/L 13.5 (5-45) ×10(9)/L, =0.001 after 6 months therapy. After 12 months, the statistical differences were maintained, which were platelets baseline 18 (6-61) ×10(9)/L 10.5 (5-45) ×10(9)/L, <0.001, absolute reticulocytes 0.03 (0.01-0.06) ×10(1