Abstract Along with global urbanization and the dominant trend toward urban‐based policies, traditional villages are facing imbalanced development and the fate of revitalization or decline. In this study, 1,222 Chinese traditional villages in eight provinces the Yellow River flows through have been selected as the typical physical bearers of Chinese civilization of an investigation into the multi‐scale spatial characteristics, and multiple influencing factors and mechanisms for regional patterns and spatial differentiation. Spatial analysis methods, including nearest neighbor index and kernel density, are applied to figure out the great regional differentiation in the overall pattern and specific distribution characteristics in each province. Physical environment factors and socioeconomic influencing factors are analyzed and compared using geographical detectors. The results show that: (a) The overall spatial distribution of the traditional villages shows great regional differentiation and is characterized by “two cores,” “three distribution modes,” and “four types of the absence” of traditional villages; (b) the spatial distribution of traditional villages in the Yellow River Basin is affected both by natural factors and by socioeconomic factors, with natural factors having the greater impact; and (c) there is no inevitable correlation between the level of economic development and the rise and fall of traditional villages. By analyzing and revealing the external forces and internal motivation and influencing factors of renewal and evolution, and the wisdom and culture behind the physical places, this research can deepen the understanding of traditional villages, enable traditional society to better adapt to contemporary society, and provide reference for rural revitalization and regional development of rural areas and the Yellow River Basin.