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  • Evaluation of the antifunga...
    Maziere, M; Andrade, J C; Rompante, P; Rodrigues, C F

    Critical reviews in microbiology, 2024-Mar-18
    Journal Article

    In 2022, the World Health Organization published a report encouraging researchers to focus on spp. to strengthen the global response to fungal oral infections and antifungal resistance. In the context of innovative research, it seems pertinent to investigate the antifungal potential of natural extracts of plants and the methodology involved in the recent reports. The aim of this systematic review is to identify the current state of research on the evaluation of the ability of plant extracts to inhibit spp. A bibliographic search has been developed to on a 10-year period to identify which plant extracts have an antifungal effect on the spp. found in the oral cavity. A total of 20 papers were reviewed and fulfilled all the selection criteria and were included in the full data analysis. Plants have been tested in a wide range of states - whole extracts, extraction of particular components such as flavonoids or polyphenols, or even using the plant to synthesize nanoparticles. Of forty-five plants tested, five of them did not show any effect against spp., which weren't part of the same family. There is a wide range of plant that exhibit antifungal proprieties. Many plants have been tested in a wide range of states - whole extracts, extraction of components such as flavonoids or polyphenols, or even using the plant to synthetize nanoparticles. The combination of plants, the addition of plants to a traditional antifungal and the interference with adhesion provided by some plants seem to be promising strategies. Nonetheless, on contrary to drugs, there is a critical lack of standardization on methodologies and protocols, which makes it difficult to compare data and, consequently, to conclude, beyond doubts, about the most promising plants to fight spp. oral infections.