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Williams, S; Brammeld, J; Aben, N; Michaut, M; Iorio, F; Wessels, L; Garnett, M; McDermott, U
European journal of cancer (1990), 12/2016, Letnik: 69Journal Article
An abstract of the study by Williams et al performing a high-throughput combinatorial siRNA screen of the human kinome across a panel of 33 colorectal cancer cell lines to identify synthetic lethal combinations and potential targets for therapy is presented. In this study, the screen utilised inhibitors of EGFR, MEK and PI3K in combination with the siRNA library to identify synergistic gene interaction events. Genomic and proteomic data were utilised in order to identify biomarker signatures that could be used to stratify patient populations that are predicted to be sensitive to these novel combinations.
