Recent technological advances in communications and computation have spurred a broad interest in control law architectures involving the monitoring, coordination, integration, and operation of sensing, computing, and communication components that tightly interact with the physical processes that they control. These systems are known as cyber-physical systems and due to their use of open computation and communication platform architectures, controlled cyber-physical systems are vulnerable to adversarial attacks. In this technical note, we propose a novel adaptive control architecture for addressing security and safety in cyber-physical systems. Specifically, we develop an adaptive controller that guarantees uniform ultimate boundedness of the closed-loop dynamical system in the face of adversarial sensor and actuator attacks that are time-varying and partial asymptotic stability when the sensor and actuator attacks are time-invariant. Finally, we provide a numerical example to illustrate the efficacy of the proposed adaptive control architecture.