Po brzini primjene i osmišljenosti inovativnih rješenja za suzbijanje zaraza pojedini elementi dubrovačkoga modela smatraju se pretečom protuepidemijskih mjera u Europi. U radu se razmatraju okolnosti nastanka toga modela u prvom stoljeću kuge i utvrđuju najvažnija obilježja temeljnih elemenata dubrovačkoga sustava za suzbijanje zaraza. Polazeći od spoznaje da su mjere za obranu od zaraza djelo vlastelina-poduzetnika, pokazuje se ključni utjecaj gospodarstva na oblikovanje tih mjera. As for the speed of implementation and the innovative solutions in controlling infectious diseases, certain elements of the Dubrovnik model are considered to be the forerunners of anti-epidemic measures in Europe. This paper discusses the circumstances of the emergence of this model in the first century of the Black Death, identifying the most important features of the basic elements of Dubrovnik’s system for controlling infectious diseases. Starting from the insight that the measures for protection against infectious diseases resulted from the efforts of entrepreneurial noblemen, the key impact of economy on these measures is discussed.