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Baron, John A; Barry, Elizabeth L; Mott, Leila A; Rees, Judy R; Sandler, Robert S; Snover, Dale C; Bostick, Roberd M; Ivanova, Anastasia; Cole, Bernard F; Ahnen, Dennis J; Beck, Gerald J; Bresalier, Robert S; Burke, Carol A; Church, Timothy R; Cruz-Correa, Marcia; Figueiredo, Jane C; Goodman, Michael; Kim, Adam S; Robertson, Douglas J; Rothstein, Richard; Shaukat, Aasma; Seabrook, March E; Summers, Robert W
New England journal of medicine/The New England journal of medicine, 10/2015, Letnik: 373, Številka: 16Journal Article
In this placebo-controlled trial involving patients with recently diagnosed adenomas, daily supplementation with vitamin D 3 (1000 IU), calcium (1200 mg), or both did not reduce the risk of recurrent colorectal adenomas over 3 to 5 years. Vitamin D, an essential nutrient that is important for bone mineralization and calcium homeostasis, 1 also has effects beyond bone and calcium. Many studies have shown it to be antineoplastic, particularly in the colorectum. In in vitro studies, vitamin D and its analogues have been shown to inhibit proliferation, induce differentiation, inhibit angiogenesis, and promote apoptosis in epithelial tissues. 2 , 3 High vitamin D intake inhibits experimental carcinogenesis, 2 , 3 even in animals that are vitamin D–replete. 4 Observational studies of vitamin D intake 5 – 7 and serum levels of 25-hydroxyvitamin D 8 – 10 have shown inverse associations between these measures and the risk of colorectal . . .
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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