To analyze the characteristics of serum antibody reactivity of cystic echinococcosis (CE) patients with different clinical status towards five native antigens obtained from Echinococcus granulosus (Eg). The protoscolex somatic soluble antigen (EgPS), crude hydatid cyst fluid antigen (EgHF), partially purified hydatid fluid antigen (Burstein's antigen, EgBu), adult somatic soluble antigen (EgAs) and the native antigen B (EgAgB) were pre- pared. 369 serum samples from CE patients and 281 sera samples from healthy individuals were examined for the antibodies against 5 native antigens with indirect ELISA. The serologic results were classified according to clinical status, and the statistical analyses were carried out to understand the relationship between the results of different antigen-ELISA and the clinical status of patients. The results of EgBu, EgAS and EgAgB-ELISA showed that the antibody positive rate in hepatic CE patients 74.1% (212/286), 73.4% (210/286), 63.6% (182/286) was significantly higher than