E-viri
Recenzirano
Odprti dostop
-
Anand, Shankara; Ardlie, Kristin G.; Graubert, Aaron; Hadley, Kane; Handsaker, Robert E.; Huang, Katherine H.; Kashin, Seva; Li, Xiao; MacArthur, Daniel G.; Meier, Samuel R.; Segrè, Ayellet V.; Barbeira, Alvaro N.; Battle, Alexis; Cotter, Daniel J.; Das, Sayantan; de Goede, Olivia M.; Einson, Jonah; Ferraro, Nicole M.; Fresard, Laure; Gamazon, Eric R.; Gay, Nicole R.; Gloudemans, Michael J.; Guigó, Roderic; Hame, Andrew R.; He, Yuan; Hoffman, Paul J.; Im, Hae Kyung; Jo, Brian; Kasela, Silva; Li, Xin; Mangul, Serghei; Mohammadi, Pejman; Montgomery, Stephen B.; Muñoz-Aguirre, Manuel; Nobel, Andrew B.; Oliva, Meritxell; Parsana, Princy; Rao, Abhiram S.; Reverter, Ferran; Sabatti, Chiara; Saha, Ashis; Strober, Benjamin J.; Teran, Nicole A.; Viñuela, Ana; Wen, Xiaoquan; Ferreira, Pedro G.; Yeger-Lotem, Esti; Barcus, Mary E.; Bradbury, Debra; Krubit, Tanya; McLean, Jeffrey A.; Qi, Liqun; Robinson, Karna; Smith, Anna M.; Sobin, Leslie; Tabor, David E.; Bridge, Jason; Foster, Barbara A.; Hunter, Marcus; Johns, Christopher; Johnson, Mark; Karasik, Ellen; Kopen, Gene; Moser, Michael T.; Roe, Brian; Shad, Saboor; Thomas, Jeffrey A.; Washington, Michael; Rohrer, Daniel C.; Valley, Dana R.; Davis, David A.; Mash, Deborah C.; Mosavel, Maghboeba; Siminoff, Laura A.; Flicek, Paul; Juettemann, Thomas; Kent, W. James; Powell, Conner C.; Rosenbloom, Kate R.; Ruffier, Magali; Sheppard, Dan; Taylor, Kieron; Abell, Nathan S.; Akey, Joshua; Demanelis, Kathryn; Feinberg, Andrew P.; Hansen, Kasper D.; Jiang, Lihua; Kibriya, Muhammad G.; Li, Jin Billy; Li, Qin; Lin, Shin; Pierce, Brandon L.; Skol, Andrew D.; Snyder, Michael; Stamatoyannopoulos, John; Tang, Hua; Guan, Ping; Nierras, Concepcion R.; Rao, Abhi K.
Science (American Association for the Advancement of Science), 09/2020, Letnik: 369, Številka: 6509Journal Article
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations. Here, we present analyses of the version 8 data, examining 15,201 RNA-sequencing samples from 49 tissues of 838 postmortem donors. We comprehensively characterize genetic associations for gene expression and splicing in cis and trans, showing that regulatory associations are found for almost all genes, and describe the underlying molecular mechanisms and their contribution to allelic heterogeneity and pleiotropy of complex traits. Leveraging the large diversity of tissues, we provide insights into the tissue specificity of genetic effects and show that cell type composition is a key factor in understanding gene regulatory mechanisms in human tissues.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.