A variety of electronic phases in solid-state systems can be understood by abstracting away microscopic details and refocusing on how Fermi surface topology interacts with band structure to define available electron states1. In fact, topological concepts are broadly applicable to non-electronic materials and can be used to understand a variety of seemingly unrelated phenomena2–6. Here, we apply topological principles to origami-inspired mechanical metamaterials7–12, and demonstrate how to guide bulk kinematics by tailoring the crease configuration-space topology. Specifically, we show that by simply changing the crease angles, we modify the configuration-space topology, and drive origami structures to dramatically change their kinematics from being smoothly and continuously deformable to mechanically bistable and rigid. In addition, we examine how a topologically disjointed configuration space can be used to constrain the locally accessible deformations of a single folded sheet. While analyses of origami structures are typically dependent on the energetics of constitutive relations11–14, the topological abstractions introduced here are a separate and independent consideration that we use to analyse, understand and design these metamaterials.