E-viri
Recenzirano
Odprti dostop
-
Risal, Sanjiv; Pei, Yu; Lu, Haojiang; Manti, Maria; Fornes, Romina; Pui, Han-Pin; Zhao, Zhiyi; Massart, Julie; Ohlsson, Claes; Lindgren, Eva; Crisosto, Nicolas; Maliqueo, Manuel; Echiburú, Barbara; Ladrón de Guevara, Amanda; Sir-Petermann, Teresa; Larsson, Henrik; Rosenqvist, Mina A; Cesta, Carolyn E; Benrick, Anna; Deng, Qiaolin; Stener-Victorin, Elisabet
Nature medicine, 12/2019, Letnik: 25, Številka: 12Journal Article
How obesity and elevated androgen levels in women with polycystic ovary syndrome (PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a clinical case-control study from Chile, we found that daughters of mothers with PCOS were more likely to be diagnosed with PCOS. Furthermore, female mice (F ) with PCOS-like traits induced by late-gestation injection of dihydrotestosterone, with and without obesity, produced female F -F offspring with PCOS-like reproductive and metabolic phenotypes. Sequencing of single metaphase II oocytes from F -F offspring revealed common and unique altered gene expression across all generations. Notably, four genes were also differentially expressed in serum samples from daughters in the case-control study and unrelated women with PCOS. Our findings provide evidence of transgenerational effects in female offspring of mothers with PCOS and identify possible candidate genes for the prediction of a PCOS phenotype in future generations.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.