E-viri
Recenzirano
Odprti dostop
-
Rothwell, Dominic G; Ayub, Mahmood; Cook, Natalie; Thistlethwaite, Fiona; Carter, Louise; Dean, Emma; Smith, Nigel; Villa, Shaun; Dransfield, Joanne; Clipson, Alexandra; White, Daniel; Nessa, Kamrun; Ferdous, Saba; Howell, Matthew; Gupta, Avinash; Kilerci, Bedirhan; Mohan, Sumitra; Frese, Kris; Gulati, Sakshi; Miller, Crispin; Jordan, Allan; Eaton, Helen; Hickson, Nicholas; O'Brien, Ciara; Graham, Donna; Kelly, Claire; Aruketty, Sreeja; Metcalf, Robert; Chiramel, Jaseela; Tinsley, Nadina; Vickers, Alexander J; Kurup, Roopa; Frost, Hannah; Stevenson, Julie; Southam, Siobhan; Landers, Dónal; Wallace, Andrew; Marais, Richard; Hughes, Andrew M; Brady, Ged; Dive, Caroline; Krebs, Matthew G
Nature medicine, 05/2019, Letnik: 25, Številka: 5Journal Article
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic. TARGET is a molecular profiling program with the primary aim to match patients with a broad range of advanced cancers to early phase clinical trials on the basis of analysis of both somatic mutations and copy number alterations (CNA) across a 641 cancer-associated-gene panel in a single ctDNA assay. For the first 100 TARGET patients, ctDNA data showed good concordance with matched tumor and results were turned round within a clinically acceptable timeframe for Molecular Tumor Board (MTB) review. When a 2.5% variant allele frequency (VAF) threshold was applied, actionable mutations were identified in 41 of 100 patients, and 11 of these patients received a matched therapy. These data support the application of ctDNA in this early phase trial setting where broad genomic profiling of contemporaneous tumor material enhances patient stratification to novel therapies and provides a practical template for bringing routinely applied blood-based analyses to the clinic.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.