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Ogata, Osamu; Nara, Hideki; Fujiwhara, Mitsuhiko; Matsumura, Kazuhiko; Kayaki, Yoshihito
Organic letters, 07/2018, Letnik: 20, Številka: 13Journal Article
The use of methanol for the selective methylation of aromatic amines with RuHCl(CO)(PN P) (PN P = bis(2-diphenylphosphinoethyl)amine) is reported. Various aromatic amines were transformed into their corresponding monomethylated secondary amines in high yields at 150 °C with a very low catalyst loading (0.02-0.1 mol %) in the presence of KO Bu (20-60 mol %). The catalyst precursor, RuHCl(CO)(PN P), was converted to RuH(CO) (PN P) under the catalytic conditions and also serves as a highly effective catalyst. The robustness of this catalyst contributes to its outstanding catalytic activity, even under reaction conditions, in which CO is liberated from methanol.
