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DeFilipp, Zachariah; Couriel, Daniel R; Lazaryan, Aleksandr; Bhatt, Vijaya Raj; Buxbaum, Nataliya P; Alousi, Amin M; Olivieri, Attilio; Pulanic, Drazen; Halter, Joerg P; Henderson, Lori A; Zeiser, Robert; Gooley, Ted A; MacDonald, Kelli P A; Wolff, Daniel; Schultz, Kirk R; Paczesny, Sophie; Inamoto, Yoshihiro; Cutler, Corey S; Kitko, Carrie L; Pidala, Joseph A; Lee, Stephanie J; Socie, Gerard; Sarantopoulos, Stefanie; Pavletic, Steven Z; Martin, Paul J; Blazar, Bruce R; Greinix, Hildegard T
Transplantation and cellular therapy, 09/2021, Letnik: 27, Številka: 9Journal Article
Positive results from recent clinical trials have significantly expanded current therapeutic options for patients with chronic graft-versus-host disease (GVHD). However, new insights into the associations between clinical characteristics of chronic GVHD, pathophysiologic mechanisms of disease, and the clinical and biological effects of novel therapeutic agents are required to allow for a more individualized approach to treatment. The current report is focused on setting research priorities and direction in the treatment of chronic GVHD. Detailed correlative scientific studies should be conducted in the context of clinical trials to evaluate associations between clinical outcomes and the biological effect of systemic therapeutics. For patients who require systemic therapy but not urgent initiation of glucocorticoids, clinical trials for initial systemic treatment of chronic GVHD should investigate novel agents as monotherapy without concurrently starting glucocorticoids, to avoid confounding biological, pathological, and clinical assessments. Clinical trials for treatment-refractory disease should specifically target patients with incomplete or suboptimal responses to most recent therapy who are early in their disease course. Close collaboration between academic medical centers, medical societies, and industry is needed to support an individualized, biology-based strategic approach to chronic GVHD therapy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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