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Patel, Raj N.; Patel, Dharmik M.; Rathod, Nileshkumar B.; Thakur, Dinesh G.; Patel, Sachinkumar D.; Tothadi, Srinu; Ghosh, Subhash Chandra
European journal of organic chemistry, 09/2023, Letnik: 26, Številka: 34Journal Article
Abstract A cobalt‐catalyzed, N,O‐bidentate directing group‐assisted C−H bond functionalization of benzamides with maleimides was developed for the facile access to isoindolone spirosuccinimides in good to excellent yields. This C−H bond activation and spirocyclization employing pyridine N‐oxide as directing group provided very good substrate scope and tolerated various functional groups. Furthermore, the mechanistic investigation revealed that the C−H bond activation is the rate‐determining step of this reaction.
