The continued investigations of the paranormal facilitated the development of novel theories and methodologies. Psi functioning of the living and the deceased in survival phenomena suggested the living agent psi (LAP) and discarnate psi hypotheses, but neither has demonstrated sufficient explanatory power to claim superiority in explaining survival data. Mediumship studies cannot determine whether paranormal information is sourced by means of discarnate psi or LAP, presenting the source-of-psi problem. Anomalous information can be obtained from joint sources (LAP, survival, or some other source), which supports the multiple sources of psi (MSoP) hypothesis. The maximized explanatory potential of the MSoP hypothesis makes the inclusion of the LAP and discarnate psi factors in the calculation of a Drake-S equation for post-mortem survival required and appropriate. This paper concludes that 1) the aggregate effect of skeptical explanations for survival was calculated at 65.6%, leaving 35.4% to paranormal explanations, which contradicts skeptical claims and is inconsistent with the existing laws of conventional science; 2) 16% of paranormal experiences reported among the general population appeared genuine; and 3) the calculated purified probability for all paranormal phenomena equaling 40% can be attributed to paranormal causes. This suggests reasonable plausibility of the survival hypothesis. To refine the existing factors and find new empirical factors related to known confounds and anomalous effects, future research should include more robust procedures and methods of data selection, gathering, and analysis. Keywords: Survival hypothesis, Living agent psi hypothesis (LAP), Discarnate psi hypothesis, Multiple sources of psi hypothesis (MSoP), Source-of-psi problem, Drake-S Equation.