The first report of anterior pituitary dysfunction as a result of traumatic brain injury was published in 1918 I. Subsequent reviews and case reports identified additional instances of hypopituitarism following head injury 2–4. In particular, the special article by Benvenga and coworkers 5 included 367 historical patients with TBIinduced hypopituitarism, together with new data of 15 patients from their own centre, and alerted many endocrinologists on the problem. The Authors found that in most cases (71%) hypopituitarisrn was diagnosed within one year of injury, although occasionally the diagnosis was not made for more than 20 years after the injury. Indeed, there are reports of patients with total, multiple, or isolated hypopituitarism whose clinical data revealed a history of previous TBI, many years before the endocrinological diagnosis, but the patients themselves did not recall their brain injury without prompting, or the assistance of a friend or family member 5.