E-viri
Recenzirano
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Shloznikov, B M; Donich, S G; Grebenchikova, O A; Makhmutov, R F; Likhvantsev, V V; Kuznetsov, A Iu; Peretrukin, A I; Fomchenkov, E P
Biulleten' eksperimental'noi biologii i meditsiny 109, Številka: 3Journal Article
The antinociceptive properties of dalargin (D) under nembutal anesthesia and artificial ventilation were studied in hemodynamic response to mechanical algesic stimulation in rats. D was introduced i/v (20 micrograms/kg) against a background of myoplegia with Arduan (0.1 mg/kg) and without it. The naloxon (100 micrograms/kg) prevented the protective effects of D. It is considered that injection of D (20 micrograms/kg) on the background of total myoplegia and artificial ventilation prevented hemodynamic response on algesic stimulus. Subsequent dose increase of opium peptide up to 3500 micrograms/kg does not cause amplification of protective properties.
